The role of progesterone receptor membrane component (PGRMC) in the endometrium.
Decidualization
Endometrial cancer
Endometriosis
Endometrium
Progesterone
Progesterone membrane receptors (PGRMC)
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
28
03
2022
revised:
25
04
2022
accepted:
02
05
2022
pubmed:
9
5
2022
medline:
29
6
2022
entrez:
8
5
2022
Statut:
ppublish
Résumé
PGRMC is a non-classical receptor that mediates the non-genomic responses to progesterone and is distributed in different subcellular compartments. PGRMC belongs to the membrane-associated progesterone receptor (MAPR) family. Two PGRMC subtypes (PGRMC1 and PGRMC2) have been characterized, and both are expressed in the human endometrium. PGRMC expression is differentially regulated during the menstrual cycle in the human endometrium. Although PGRMC1 is predominantly expressed in the proliferative phase and PGRMC2 in the secretory phase, this expression changes in pathologies such as endometriosis, in which PGRMC2 expression considerably decreases, promoting progesterone resistance. In endometrial cancer, PGRMC1 is overexpressed, its activation induces tumors growth, and confers chemoresistance in the presence of progesterone. Thus, PGRMCs play a key role in progesterone actions in the endometrium.
Identifiants
pubmed: 35526781
pii: S0039-128X(22)00078-2
doi: 10.1016/j.steroids.2022.109040
pii:
doi:
Substances chimiques
Membrane Proteins
0
PGRMC1 protein, human
0
PGRMC2 protein, human
0
Receptors, Progesterone
0
Progesterone
4G7DS2Q64Y
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109040Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.