Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease.
chronic kidney disease
mineralocorticoid receptor
nonepithelial cells
Journal
Kidney international supplements
ISSN: 2157-1724
Titre abrégé: Kidney Int Suppl (2011)
Pays: United States
ID NLM: 101562008
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
26
07
2021
revised:
01
11
2021
accepted:
08
11
2021
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
ppublish
Résumé
Chronic kidney disease is a major global health challenge, and mineralocorticoid receptor (MR) signaling is thought to play a role in disease progression. The classic role of the MR is the regulation of fluid and electrolyte homeostasis via differential gene expression, and recently its role in modulating inflammation and fibrosis has been identified. In addition to expression of the MR in renal epithelial cells, it is also found in nonepithelial cells, such as endothelial cells, vascular smooth muscle cells, podocytes, and fibroblasts. Targeting the MR in these cells may play a role in offering protection against inflammation and fibrosis in the kidneys and the cardiovascular system. Herein, data from preclinical cell-specific MR knockout mouse models and
Identifiants
pubmed: 35529084
doi: 10.1016/j.kisu.2021.11.004
pii: S2157-1716(21)00067-8
pmc: PMC9073223
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
12-18Informations de copyright
© 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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