Role of Long Noncoding RNAs in Smoking-Induced Lung Cancer: An In Silico Study.
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
10
2021
revised:
13
03
2022
accepted:
05
04
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
The prevalence of lung cancer induced by cigarette smoking has increased over time. Long noncoding (lnc) RNAs, regulatory factors that play a role in human diseases, are commonly dysregulated in lung cancer. Cigarette smoking is closely related to changes in lncRNA expression, which can affect lung cancer. Herein, we assess the mechanism of lung cancer initiation induced by smoking. To calculate the impact of smoking on the survival of patients with lung cancer, we extracted data from The Cancer Genome Atlas and Gene Expression Omnibus databases and identified the differentially expressed genes in the lung cancer tissue compared to the normal lung tissue. Genes positively and negatively associated with smoking were identified. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Cytoscape analyses were performed to determine the function of the genes and the effects of smoking on the immune microenvironment. lncRNAs corresponding to smoking-associated genes were identified, and a smoking-related lncRNA model was constructed using univariate and multivariate Cox analyses. This model was used to assess the survival of and potential risk in patients who smoked. During screening, 562 differentially expressed genes were identified, and we elucidated that smoking affected the survival of patients 4.5 years after the diagnosis of lung cancer. Furthermore, genes negatively associated with smoking were closely associated with immunity. Twelve immune cell types were also found to infiltrate differentially in smokers and nonsmokers. Thus, the smoking-associated lncRNA model is a good predictor of survival and risk in smokers and may be used as an independent prognostic factor for lung cancer.
Identifiants
pubmed: 35529255
doi: 10.1155/2022/7169353
pmc: PMC9070410
doi:
Substances chimiques
Biomarkers, Tumor
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7169353Informations de copyright
Copyright © 2022 Lei Ge et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
Références
Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):141-51
pubmed: 22232023
SSM Popul Health. 2019 Jan 11;7:100349
pubmed: 30723766
Cancer Res. 2016 Jun 1;76(11):3189-99
pubmed: 27197187
Sultan Qaboos Univ Med J. 2013 Aug;13(3):345-58
pubmed: 23984018
Chem Res Toxicol. 2001 Jul;14(7):767-90
pubmed: 11453723
Cancer Res. 1984 Dec;44(12 Pt 1):5940-58
pubmed: 6388830
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Lancet. 2017 May 13;389(10082):1885-1906
pubmed: 28390697
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
N Engl J Med. 2008 Sep 25;359(13):1367-80
pubmed: 18815398
Cancer Prev Res (Phila). 2016 Jul;9(7):518-27
pubmed: 27006378
Cell Immunol. 2008 May-Jun;253(1-2):38-44
pubmed: 18533139
Ann Rheum Dis. 2011 Mar;70(3):508-11
pubmed: 21149499
Trends Genet. 2018 Feb;34(2):142-157
pubmed: 29249332
Cancer Res. 2020 Jul 1;80(13):2718-2719
pubmed: 32616506
N Engl J Med. 2011 Aug 4;365(5):395-409
pubmed: 21714641
Chem Biol Interact. 2020 Sep 25;329:109210
pubmed: 32726580
Int J Mol Sci. 2019 Aug 01;20(15):
pubmed: 31374807
Exp Ther Med. 2018 Dec;16(6):4991-5002
pubmed: 30542454
Lancet Oncol. 2002 Aug;3(8):461-9
pubmed: 12147432
Thorac Cancer. 2017 Nov;8(6):672-681
pubmed: 28949095
BMJ. 2019 Jun 3;365:l1725
pubmed: 31160279
Lancet Oncol. 2019 Dec;20(12):1622-1623
pubmed: 31669156
Circ Cardiovasc Genet. 2016 Oct;9(5):436-447
pubmed: 27651444
J Cell Mol Med. 2020 Jan;24(2):1319-1331
pubmed: 31769590
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Lancet. 2011 Nov 12;378(9804):1727-40
pubmed: 21565398
Thorax. 2017 Dec;72(12):1084-1093
pubmed: 28720648
Int Immunopharmacol. 2020 Dec;89(Pt A):107053
pubmed: 33045568
J Leukoc Biol. 2012 Sep;92(3):621-31
pubmed: 22427682
J Autoimmun. 2017 Mar;78:101-110
pubmed: 28082047
Nat Rev Immunol. 2014 Feb;14(2):81-93
pubmed: 24445666
Lancet. 2018 Mar 17;391(10125):1023-1075
pubmed: 29395269
Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):3-9
pubmed: 24420982
Trends Cell Biol. 2018 Apr;28(4):287-301
pubmed: 29274663
Brain. 2011 Mar;134(Pt 3):653-64
pubmed: 21303861
Oncotarget. 2016 Sep 13;7(37):60503-60518
pubmed: 27556357
Am J Respir Cell Mol Biol. 2003 Aug;29(2):157-62
pubmed: 12600827
PeerJ. 2020 Oct 05;8:e9996
pubmed: 33083119
Sci Rep. 2018 May 15;8(1):7609
pubmed: 29765063
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3493-8
pubmed: 25733882
PLoS One. 2013 Sep 13;8(9):e72975
pubmed: 24058452
Lancet Respir Med. 2020 Jul;8(7):664-665
pubmed: 32464099
Front Oncol. 2021 Mar 31;11:613198
pubmed: 33868998
Arch Bronconeumol (Engl Ed). 2018 Jun;54(6):301-302
pubmed: 29422343