Efficacy and Prognosis of Hyperbaric Oxygen as Adjuvant Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Meta-Analysis Study.
hyperbaric oxygen therapy
hypoxic-ischemic encephalopathy
meta-analysis
neonate
randomized controlled trials
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
05
2021
accepted:
09
03
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
epublish
Résumé
Preclinical and clinical evidence suggests that hyperbaric oxygen therapy (HBOT) may benefit newborns. The effectiveness of HBOT for neonatal hypoxic-ischemic encephalopathy (HIE) remains controversial. We conducted a meta-analysis to evaluate the efficacy and prognosis of HBOT in neonates with HIE. A systematic search of eight databases was performed for available articles published between January 1, 2015, and September 30, 2020, to identify randomized controlled clinical trials (RCTs) on HBOT for neonatal HIE. Methodological quality assessment was performed by applying the simple procedure detailed by the Cochrane collaboration. Afterward, quality assessment and data analysis were performed using Revman 5.3 software. STATA 15 software was used to detect publication bias as well as for sensitivity analysis. A total of 46 clinical RCTs were selected for the study and included 4,199 patients with neonatal HIE. The results indicated that HBOT significantly improved the total efficiency (TEF) of treatment for neonatal HIE patients [odds ratio (OR) = 4.61, 95% confidence interval (CI) (3.70, 5.75), In light of the effectiveness of HBOT neonatal HIE, this meta-analysis suggested that HBOT can be a potential therapy for the treatment of neonatal HIE. Due to the heterogeneity of studies protocol and patient selection being only from China, more research is needed before this therapy can be widely implemented in the clinic. PROSPERO (ID: CRD42020210639). Available online at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020210639.
Sections du résumé
Background
UNASSIGNED
Preclinical and clinical evidence suggests that hyperbaric oxygen therapy (HBOT) may benefit newborns. The effectiveness of HBOT for neonatal hypoxic-ischemic encephalopathy (HIE) remains controversial. We conducted a meta-analysis to evaluate the efficacy and prognosis of HBOT in neonates with HIE.
Methods
UNASSIGNED
A systematic search of eight databases was performed for available articles published between January 1, 2015, and September 30, 2020, to identify randomized controlled clinical trials (RCTs) on HBOT for neonatal HIE. Methodological quality assessment was performed by applying the simple procedure detailed by the Cochrane collaboration. Afterward, quality assessment and data analysis were performed using Revman 5.3 software. STATA 15 software was used to detect publication bias as well as for sensitivity analysis.
Results
UNASSIGNED
A total of 46 clinical RCTs were selected for the study and included 4,199 patients with neonatal HIE. The results indicated that HBOT significantly improved the total efficiency (TEF) of treatment for neonatal HIE patients [odds ratio (OR) = 4.61, 95% confidence interval (CI) (3.70, 5.75),
Conclusion
UNASSIGNED
In light of the effectiveness of HBOT neonatal HIE, this meta-analysis suggested that HBOT can be a potential therapy for the treatment of neonatal HIE. Due to the heterogeneity of studies protocol and patient selection being only from China, more research is needed before this therapy can be widely implemented in the clinic.
Protocol Registration
UNASSIGNED
PROSPERO (ID: CRD42020210639). Available online at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020210639.
Identifiants
pubmed: 35529335
doi: 10.3389/fped.2022.707136
pmc: PMC9069061
doi:
Types de publication
Journal Article
Langues
eng
Pagination
707136Informations de copyright
Copyright © 2022 Gong, Feng, Dong, Liu, Gu, Jiang, Lou, Xu and Dou.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Pediatr Res. 2018 Jan;83(1-2):356-363
pubmed: 29016557
Curr Treat Options Neurol. 2012 Dec;14(6):608-19
pubmed: 23007949
Clin Exp Optom. 2015 Mar;98(2):122-5
pubmed: 25308346
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
PLoS One. 2016 Feb 09;11(2):e0148324
pubmed: 26859390
Prog Neurobiol. 2017 Dec;159:50-68
pubmed: 29111451
Int J Mol Sci. 2020 Feb 21;21(4):
pubmed: 32098276
Acta Cir Bras. 2017 Apr;32(4):270-279
pubmed: 28538801
Front Biosci (Landmark Ed). 2018 Jun 1;23(12):2204-2226
pubmed: 29772556
J Transl Med. 2018 Sep 12;16(1):255
pubmed: 30208940
Expert Rev Neurother. 2017 May;17(5):449-459
pubmed: 27830959
BMJ. 2006 Aug 19;333(7564):374
pubmed: 16690641
Arch Dis Child Fetal Neonatal Ed. 2017 Jul;102(4):F346-F358
pubmed: 28389438
Neural Regen Res. 2013 May 5;8(13):1220-7
pubmed: 25206416
Acta Paediatr. 1997 Jul;86(7):757-61
pubmed: 9240886
Arch Neurol. 1976 Oct;33(10):696-705
pubmed: 987769
Early Hum Dev. 2010 Jun;86(6):329-38
pubmed: 20554402
Prog Neurobiol. 2019 Feb;173:1-17
pubmed: 29758244
Acta Neurol Belg. 2020 Apr;120(2):277-288
pubmed: 32112349
Clin Perinatol. 2014 Mar;41(1):119-31
pubmed: 24524450
Neurosci Lett. 2009 Nov 13;465(2):171-6
pubmed: 19765636
Brain Behav. 2018 Mar 30;8(5):e00959
pubmed: 29761012
Neurol India. 2019 May-Jun;67(3):728-731
pubmed: 31347544
Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):133-5
pubmed: 18433528
Free Radic Res. 2016;50(4):454-66
pubmed: 26729624
Clin Biochem. 2004 Apr;37(4):312-7
pubmed: 15003734
Crit Care Nurs Clin North Am. 2018 Dec;30(4):509-521
pubmed: 30447810
NeuroRehabilitation. 2010;26(1):5-13
pubmed: 20130351
Continuum (Minneap Minn). 2018 Feb;24(1, Child Neurology):57-71
pubmed: 29432237
Cochrane Database Syst Rev. 2014 Nov 12;(11):CD004954
pubmed: 25387992
Neurol Sci. 2016 May;37(5):693-701
pubmed: 26746238
Neural Plast. 2016;2016:4901014
pubmed: 27047695
J Evid Based Med. 2015 Feb;8(1):2-10
pubmed: 25594108
J Child Neurol. 2015 Jan;30(1):75-82
pubmed: 24762865