Immune Response to Third Dose BNT162b2 COVID-19 Vaccine Among Kidney Transplant Recipients-A Prospective Study.
COVID-19 vaccine
antibody response
cellular response
immunosuppression reduction
kidney transplant recipients
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
11
2021
accepted:
08
03
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
Immune response to two SARS-CoV-2 mRNA vaccine doses among kidney transplant recipients (KTRs) is limited. We aimed to evaluate humoral and cellular response to a third BNT162b2 dose. In this prospective study, 190 KTRs were evaluated before and ∼3 weeks after the third vaccine dose. The primary outcomes were anti-spike antibody level >4160 AU/ml (neutralization-associated cutoff) and any seropositivity. Univariate and multivariate analyses were conducted to identify variables associated with antibody response. T-cell response was evaluated in a subset of participants. Results were compared to a control group of 56 healthcare workers. Among KTRs, we found a seropositivity rate of 70% (133/190) after the third dose (37%, 70/190, after the second vaccine dose); and 27% (52/190) achieved levels above 4160 AU/ml after the third dose, compared to 93% of controls. Variables associated with antibody response included higher antibody levels after the second dose (odds ratio [OR] 30.8 per log AU/ml, 95% confidence interval [CI]11-86.4,
Identifiants
pubmed: 35529596
doi: 10.3389/ti.2022.10204
pii: 10204
pmc: PMC9068869
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Vaccines, Synthetic
0
mRNA Vaccines
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10204Informations de copyright
Copyright © 2022 Yahav, Rahamimov, Mashraki, Ben-Dor, Steinmetz, Agur, Zingerman, Herman-Edelstein, Lichtenberg, Ben-Zvi, Bar-Haim, Cohen, Rotem, Elia, Margalit and Zvi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet Reg Health Eur. 2021 Oct;9:100178
pubmed: 34318288
Lancet Respir Med. 2021 Jun;9(6):e52-e53
pubmed: 33964244
Nat Med. 2021 Jun;27(6):981-984
pubmed: 33795870
JAMA. 2021 Oct 19;326(15):1533-1535
pubmed: 34459863
Immunol Res. 2021 Dec;69(6):576-583
pubmed: 34417958
J Am Soc Nephrol. 2021 Oct 19;:
pubmed: 34667083
J Clin Virol. 2022 Mar;148:105098
pubmed: 35134681
Clin Transplant. 2019 Oct;33(10):e13707
pubmed: 31494965
Lancet. 2021 Jul 24;398(10297):298-299
pubmed: 34270933
J Hepatol. 2021 Aug;75(2):435-438
pubmed: 33892006
Am J Transplant. 2022 Mar;22(3):786-800
pubmed: 34551187
N Engl J Med. 2021 Sep 23;385(13):1233-1234
pubmed: 34379913
N Engl J Med. 2021 Aug 12;385(7):661-662
pubmed: 34161700
N Engl J Med. 2022 Feb 10;386(6):509-520
pubmed: 34914868
N Engl J Med. 2021 Sep 23;385(13):1244-1246
pubmed: 34379917
JAMA. 2021 Jul 23;:
pubmed: 34297036
Transplantation. 2006 Jul 15;82(1):55-61
pubmed: 16861942
Nat Med. 2021 Nov;27(11):2002-2011
pubmed: 34594036
Clin Microbiol Infect. 2021 Aug;27(8):1173.e1-1173.e4
pubmed: 33957273
EBioMedicine. 2021 Nov;73:103679
pubmed: 34763205
Lancet Rheumatol. 2021 Nov;3(11):e756
pubmed: 34608457
N Engl J Med. 2021 Nov 18;385(21):1941-1950
pubmed: 34706189
Eur J Heart Fail. 2021 Sep;23(9):1555-1559
pubmed: 33963635
JAMA Netw Open. 2021 Nov 1;4(11):e2136030
pubmed: 34817587
Lancet Reg Health Eur. 2021 Nov;10:100208
pubmed: 34514454
Ann Intern Med. 2022 Mar;175(3):455-456
pubmed: 35007148
Transplantation. 2021 Dec 1;105(12):e280-e281
pubmed: 34428188
Ann Intern Med. 2021 Sep;174(9):1330-1332
pubmed: 34125572
JAMA. 2021 Jun 1;325(21):2204-2206
pubmed: 33950155
JAMA. 2022 Jan 25;327(4):341-349
pubmed: 35006256
Am J Transplant. 2021 Aug;21(8):2910-2912
pubmed: 34043872
Kidney Int. 2021 Aug;100(2):477-479
pubmed: 34029554