Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial.
BDNF
aerobic exercise
brain volume
combined training
computerized cognitive training
neuroinflammation
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
01
2022
accepted:
16
03
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
epublish
Résumé
Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week (5 days per week-45 min per day) multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise (AE), computerized cognitive training (CCT) and a combined (COMB) groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited (62% female; age = 58.38 ± 5.47). In this study we report intervention-related changes in plasma biomarkers (BDNF, TNF-α, HGF, ICAM-1, SDF1-α) and structural-MRI (brain volume) and how they related to changes in physical activity and individual variables (age and sex) and their potential role as mediators in the cognitive changes. Our results show that although there were no significant changes in molecular biomarker concentrations in any intervention group, changes in ICAM-1 and SDF1-α were negatively associated with changes in physical activity outcomes in AE and COMB groups. Brain volume changes were found in the CCT showing a significant increase in precuneus volume. Sex moderated the brain volume change in the AE and COMB groups, suggesting that men may benefit more than women. Changes in molecular biomarkers and brain volumes did not significantly mediate the cognitive-related benefits found previously for any group. This study shows crucial initial molecular and brain volume changes related to lifestyle interventions at early stages and highlights the value of examining activity parameters, individual difference characteristics and using a multi-level analysis approach to address these questions.
Identifiants
pubmed: 35529777
doi: 10.3389/fnhum.2022.854175
pmc: PMC9067321
doi:
Types de publication
Journal Article
Langues
eng
Pagination
854175Informations de copyright
Copyright © 2022 Castells-Sánchez, Roig-Coll, Dacosta-Aguayo, Lamonja-Vicente, Torán-Monserrat, Pera, García-Molina, Tormos, Montero-Alía, Heras-Tébar, Soriano-Raya, Cáceres, Domènech, Via, Erickson and Mataró.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Aging Neurosci. 2019 Dec 06;11:329
pubmed: 31866852
Transl Psychiatry. 2017 Jul 18;7(7):e1172
pubmed: 28934191
BMC Med Inform Decis Mak. 2014 Jul 19;14:58
pubmed: 25038823
Neurobiol Aging. 2014 Sep;35 Suppl 2:S20-8
pubmed: 24952993
Br J Sports Med. 2018 Feb;52(3):154-160
pubmed: 28438770
Med Sci Sports Exerc. 1987 Jun;19(3):253-9
pubmed: 3600239
Front Syst Neurosci. 2015 Apr 01;9:44
pubmed: 25883555
J Alzheimers Dis. 2017;59(3):1097-1111
pubmed: 28731451
Brain Plast. 2018 Dec 12;4(1):53-63
pubmed: 30564546
Ageing Res Rev. 2021 Mar;66:101232
pubmed: 33249177
J Gerontol B Psychol Sci Soc Sci. 2021 Jan 18;76(2):219-228
pubmed: 31121030
Circ J. 2004 Apr;68(4):304-7
pubmed: 15056825
Neuroscience. 2014 Sep 5;275:81-8
pubmed: 24929068
Sports Med. 2019 Oct;49(10):1529-1546
pubmed: 31270754
Front Aging Neurosci. 2015 Mar 09;7:14
pubmed: 25805989
Cold Spring Harb Perspect Med. 2017 Oct 3;7(10):
pubmed: 28348175
Appl Physiol Nutr Metab. 2018 Nov;43(11):1095-1104
pubmed: 29775542
Atherosclerosis. 2014 Jul;235(1):150-61
pubmed: 24835434
Hippocampus. 2021 Mar;31(3):335-347
pubmed: 33315276
Neurotherapeutics. 2019 Jul;16(3):580-599
pubmed: 31197642
Neuroimage. 2009 Jun;46(2):486-99
pubmed: 19385016
Sci Rep. 2017 Jan 03;7:39471
pubmed: 28045051
Afr Health Sci. 2019 Dec;19(4):2874-2880
pubmed: 32127863
Rev Esp Salud Publica. 2012 Oct;86(5):495-508
pubmed: 23223762
Am J Geriatr Psychiatry. 2009 Mar;17(3):179-87
pubmed: 19225276
Front Neuroendocrinol. 2017 Jul;46:71-85
pubmed: 28442274
Front Aging Neurosci. 2019 Aug 14;11:216
pubmed: 31481889
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H926-H927
pubmed: 18689494
Am J Geriatr Psychiatry. 2017 Mar;25(3):209-217
pubmed: 27986412
Front Hum Neurosci. 2016 Dec 08;10:626
pubmed: 28018195
Neurobiol Aging. 2011 Jul;32(7):1304-19
pubmed: 19716631
Trends Neurosci. 2007 Sep;30(9):464-72
pubmed: 17765329
BMC Geriatr. 2017 Jul 10;17(1):139
pubmed: 28693437
Front Aging Neurosci. 2021 Mar 08;13:615247
pubmed: 33776741
Trends Neurosci. 2020 Jul;43(7):533-543
pubmed: 32409017
Neuroimage. 2011 Jan 15;54(2):940-54
pubmed: 20851199
Ageing Res Rev. 2019 Jul;52:32-52
pubmed: 31002885
Curr Transl Geriatr Exp Gerontol Rep. 2012 Apr 19;1(2):104-110
pubmed: 23864998
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
pubmed: 17167157
J Psychiatr Res. 2015 Jan;60:56-64
pubmed: 25455510
Brain. 2006 Mar;129(Pt 3):564-83
pubmed: 16399806
J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):755-763
pubmed: 31054254
Int J Prev Med. 2018 Jan 29;9:9
pubmed: 29441186
Med Sci Sports Exerc. 1982;14(5):377-81
pubmed: 7154893
J Clin Med. 2020 Mar 27;9(4):
pubmed: 32230708
Front Neurol. 2020 Dec 03;11:606873
pubmed: 33343503
Int J Environ Res Public Health. 2020 Aug 25;17(17):
pubmed: 32854323
Mol Psychiatry. 2015 May;20(5):585-93
pubmed: 25311366
J Alzheimers Dis. 2019;71(4):1245-1261
pubmed: 31498125
Am J Prev Med. 2012 Feb;42(2):109-19
pubmed: 22261206
Oxid Med Cell Longev. 2016;2016:7239639
pubmed: 26823952
Neuroimage. 2016 May 1;131:81-90
pubmed: 26477656
Physiol Behav. 2020 Sep 1;223:112923
pubmed: 32474233
J Phys Act Health. 2018 Jan 1;15(1):64-71
pubmed: 28771081
Cochrane Database Syst Rev. 2020 Feb 27;2:CD012277
pubmed: 32104914
Int J Geriatr Psychiatry. 2021 Aug;36(8):1148-1157
pubmed: 33675074
PLoS One. 2016 Sep 22;11(9):e0163037
pubmed: 27658238
Psychol Sci. 2003 Mar;14(2):125-30
pubmed: 12661673
Neural Plast. 2017;2017:3589271
pubmed: 28695017
Front Aging Neurosci. 2019 Apr 26;11:98
pubmed: 31080412
Sports Med. 2010 Sep 1;40(9):765-801
pubmed: 20726622
Med Sci Sports Exerc. 2021 Jun 1;53(6):1252-1259
pubmed: 33394900
Mayo Clin Proc. 2016 Jun;91(6):755-62
pubmed: 27161032
Am J Alzheimers Dis Other Demen. 2018 Feb;33(1):20-29
pubmed: 28946752
Neuroimage. 2018 Feb 1;166:230-238
pubmed: 29113943
Clin Interv Aging. 2018 Jul 20;13:1267-1301
pubmed: 30057444
Front Cell Neurosci. 2014 Mar 06;8:65
pubmed: 24639628
Front Physiol. 2020 Aug 25;11:1080
pubmed: 32982796
Arch Clin Neuropsychol. 2004 Mar;19(2):203-14
pubmed: 15010086
Front Aging Neurosci. 2015 Oct 13;7:187
pubmed: 26528177
Neurobiol Aging. 2012 Mar;33(3):620.e9-620.e22
pubmed: 21497950
Arch Clin Neuropsychol. 2009 Jun;24(4):395-411
pubmed: 19648583
Plast Reconstr Surg. 2015 Feb;135(2):340e-350e
pubmed: 25626819
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
pubmed: 21282661
Arch Gerontol Geriatr. 2013 Jan-Feb;56(1):10-5
pubmed: 22749404
Front Hum Neurosci. 2014 Dec 11;8:985
pubmed: 25566019
IEEE J Biomed Health Inform. 2015 Jan;19(1):124-31
pubmed: 25204001
Circ Res. 2002 Jun 14;90(11):1222-30
pubmed: 12065326
Phys Sportsmed. 2019 Nov;47(4):395-405
pubmed: 31002004
Stroke. 2015 Apr;46(4):1059-64
pubmed: 25700290
Int J Behav Nutr Phys Act. 2018 Jul 4;15(1):63
pubmed: 29973193
Neurosci Biobehav Rev. 2018 May;88:177-186
pubmed: 29572187
Front Aging Neurosci. 2016 Mar 22;8:61
pubmed: 27047376
Neuropsychologia. 2001;39(11):1150-7
pubmed: 11527552
J Neurosci. 2014 Jan 22;34(4):1224-33
pubmed: 24453314
Front Aging Neurosci. 2020 Oct 29;12:590168
pubmed: 33192485
Front Endocrinol (Lausanne). 2018 Aug 30;9:503
pubmed: 30214428