Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells.
MALAT1
lncRNA - long noncoding RNA
miRNA - microRNA
myasthenia gravis
ncRNAs (non coding RNAs)
thymic carcinoma
thymic epithelial tumors (TETs)
thymoma
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
01
2022
accepted:
21
03
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization. Long non-coding RNAs (lncRNAs) are emerging as relevant gene expression modulators involved in the deregulation of several networks in almost all types of human cancer, including TETs. LncRNAs act at different control levels in the regulation of gene expression, from transcription to translation, and modulate several pathways relevant to cell fate determination under normal and pathological conditions. The activity of lncRNAs is strongly dependent on their expression, localization, and post-transcriptional modifications. Starting from our recently published studies, this review focuses on the involvement of lncRNAs in the acquisition of malignant traits by neoplastic thymic epithelial cells, and describes the possible use of these molecules as targets for the design of novel therapeutic approaches specific for TET. Furthermore, the involvement of lncRNAs in myasthenia gravis (MG)-related thymoma, which is still under investigation, is discussed.
Identifiants
pubmed: 35529877
doi: 10.3389/fimmu.2022.867181
pmc: PMC9073009
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
867181Informations de copyright
Copyright © 2022 Iaiza, Tito, Ganci, Sacconi, Gallo, Masciarelli, Fontemaggi, Fatica, Melis, Petrozza, Venuta, Marino, Blandino and Fazi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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