Intracerebral Infection with
Alzheimer’s disease
E. coli
amyloid-β
cognitive functions
delirium
intracerebral infection
neurodegenerative disease
spatial learning
spatial memory
water maze
Journal
Journal of Alzheimer's disease reports
ISSN: 2542-4823
Titre abrégé: J Alzheimers Dis Rep
Pays: Netherlands
ID NLM: 101705500
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
10
2021
accepted:
15
02
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
epublish
Résumé
In patients with Alzheimer's disease (AD), bacterial infections are often associated with a cognitive decline. Animal models of genuine acute infections with viable bacteria which induce deterioration of neurodegenerative diseases are missing. We assessed the effect of an intracerebral infection with 13-month-old Tg2576 +/- mice and transgene negative littermates (Tg2576 -/-) received an intracerebral injection with Mortality of the infection was approximately 20%. After 4 weeks, spatial learning of infected Tg2576 +/- mice was compromised compared to non-infected Tg2576 +/- mice ( Here, we proved in principle that a genuine acute bacterial infection can worsen cognitive functions of AD mice. Mouse models of subacute systemic infections are needed to develop new strategies for the treatment of bacterial infections in patients with AD in order to minimize their cognitive decline.
Sections du résumé
Background
UNASSIGNED
In patients with Alzheimer's disease (AD), bacterial infections are often associated with a cognitive decline. Animal models of genuine acute infections with viable bacteria which induce deterioration of neurodegenerative diseases are missing.
Objective
UNASSIGNED
We assessed the effect of an intracerebral infection with
Methods
UNASSIGNED
13-month-old Tg2576 +/- mice and transgene negative littermates (Tg2576 -/-) received an intracerebral injection with
Results
UNASSIGNED
Mortality of the infection was approximately 20%. After 4 weeks, spatial learning of infected Tg2576 +/- mice was compromised compared to non-infected Tg2576 +/- mice (
Conclusion
UNASSIGNED
Here, we proved in principle that a genuine acute bacterial infection can worsen cognitive functions of AD mice. Mouse models of subacute systemic infections are needed to develop new strategies for the treatment of bacterial infections in patients with AD in order to minimize their cognitive decline.
Identifiants
pubmed: 35530117
doi: 10.3233/ADR-210049
pii: ADR210049
pmc: PMC9028720
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101-114Informations de copyright
© 2022 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to report.
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