Neuronal Redevelopment and the Regeneration of Neuromodulatory Axons in the Adult Mammalian Central Nervous System.
axon regeneration
glial scar
neuromodulatory neuron
neuronal injury and repair
redevelopment
serotonin
spinal cord injury
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
02
2022
accepted:
24
03
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
epublish
Résumé
One reason that many central nervous system injuries, including those arising from traumatic brain injury, spinal cord injury, and stroke, have limited recovery of function is that neurons within the adult mammalian CNS lack the ability to regenerate their axons following trauma. This stands in contrast to neurons of the adult mammalian peripheral nervous system (PNS). New evidence, provided by single-cell expression profiling, suggests that, following injury, both mammalian central and peripheral neurons can revert to an embryonic-like growth state which is permissive for axon regeneration. This "redevelopment" strategy could both facilitate a damage response necessary to isolate and repair the acute damage from injury and provide the intracellular machinery necessary for axon regrowth. Interestingly, serotonin neurons of the rostral group of raphe nuclei, which project their axons into the forebrain, display a robust ability to regenerate their axons unaided, counter to the widely held view that CNS axons cannot regenerate without experimental intervention after injury. Furthermore, initial evidence suggests that norepinephrine neurons within the locus coeruleus possess similar regenerative abilities. Several morphological characteristics of serotonin axon regeneration in adult mammals, observable using longitudinal
Identifiants
pubmed: 35530177
doi: 10.3389/fncel.2022.872501
pmc: PMC9074815
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
872501Informations de copyright
Copyright © 2022 Cooke, Janowitz and Dougherty.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Results Probl Cell Differ. 2009;48:339-51
pubmed: 19582408
Neuron. 2002 Jul 18;35(2):283-90
pubmed: 12160746
Science. 1981 Nov 20;214(4523):931-3
pubmed: 6171034
Dev Dyn. 1999 Jan;214(1):55-65
pubmed: 9915576
J Neurosci. 1998 Jul 1;18(13):4854-60
pubmed: 9634551
J Neurosci. 2009 Oct 28;29(43):13435-44
pubmed: 19864556
Exp Neurol. 2010 Jan;221(1):68-78
pubmed: 19840787
J Neurosci. 2013 Jun 26;33(26):10591-606
pubmed: 23804083
Elife. 2020 Jun 22;9:
pubmed: 32568072
Nat Med. 2016 May;22(5):479-87
pubmed: 27019328
J Neurosci. 1988 Aug;8(8):2788-803
pubmed: 2457659
Nat Rev Neurosci. 2010 Dec;11(12):799-811
pubmed: 21045861
J Neurosci. 2012 Nov 7;32(45):15737-46
pubmed: 23136413
Curr Opin Neurol. 2011 Dec;24(6):577-83
pubmed: 21968547
Nat Rev Neurosci. 2009 Mar;10(3):211-23
pubmed: 19190638
Nat Commun. 2013;4:2038
pubmed: 23799397
J Neurosci. 1999 Jun 1;19(11):4370-87
pubmed: 10341240
Nat Neurosci. 2009 Sep;12(9):1106-13
pubmed: 19648914
J Neurocytol. 1984 Feb;13(1):165-82
pubmed: 6707710
Neuroscience. 1978;3(10):851-60
pubmed: 215936
Biomed Res Int. 2014;2014:651625
pubmed: 25177696
Mol Cell Neurosci. 2000 Feb;15(2):170-82
pubmed: 10673325
Glia. 1994 May;11(1):18-34
pubmed: 8070892
Front Cell Neurosci. 2020 Jul 02;14:174
pubmed: 32714150
Neuron. 2003 Apr 24;38(2):201-11
pubmed: 12718855
J Biol Chem. 2014 Nov 21;289(47):32914-25
pubmed: 25296755
Brain Res Brain Res Rev. 2003 Apr;42(1):33-84
pubmed: 12668290
Prog Neurobiol. 1991;36(3):195-200
pubmed: 2017550
Exp Neurol. 2008 Feb;209(2):294-301
pubmed: 17617407
Brain Res. 1973 Sep 14;59:169-79
pubmed: 4747749
Cell Rep. 2016 Apr 12;15(2):238-46
pubmed: 27050519
J Neurosci. 2015 Jul 01;35(26):9754-63
pubmed: 26134657
J Neurosci. 2015 Apr 22;35(16):6413-28
pubmed: 25904793
J Neurosci. 2016 Feb 03;36(5):1758-74
pubmed: 26843655
Front Cell Neurosci. 2014 Oct 27;8:328
pubmed: 25386118
Mol Ther. 2016 Oct;24(10):1712-1725
pubmed: 27203446
J Neurosci. 2000 Jan 15;20(2):771-82
pubmed: 10632606
Nat Commun. 2019 Aug 28;10(1):3879
pubmed: 31462640
Nat Neurosci. 2004 Mar;7(3):221-8
pubmed: 14966521
Neurotherapeutics. 2018 Jul;15(3):554-577
pubmed: 29728852
Neuroscience. 1990;35(2):249-64
pubmed: 2116602
Trends Neurosci. 1999 Sep;22(9):377-82
pubmed: 10441294
Neurochem Res. 1992 May;17(5):449-56
pubmed: 1528354
J Comp Neurol. 2005 May 9;485(3):183-90
pubmed: 15791642
Ochsner J. 2013 Spring;13(1):100-8
pubmed: 23531634
Neuron. 2016 Aug 17;91(4):748-762
pubmed: 27499084
Blood. 2011 Jun 2;117(22):6024-35
pubmed: 21355092
J Neurosci. 1999 Jul 15;19(14):5810-22
pubmed: 10407022
Neuron. 2004 Jun 24;42(6):897-912
pubmed: 15207235
PLoS One. 2012;7(1):e30417
pubmed: 22272348
J Neurosci. 1992 Sep;12(9):3310-20
pubmed: 1527582
Brain. 2020 Jun 1;143(6):1697-1713
pubmed: 32375169
Neurosci Lett. 1991 Aug 5;129(1):107-10
pubmed: 1922958
J Neurosci. 2010 Aug 11;30(32):10899-904
pubmed: 20702718
Nat Med. 2006 Jul;12(7):829-34
pubmed: 16783372
J Neurosci Res. 2018 Apr;96(4):512-526
pubmed: 28485037
Ann N Y Acad Sci. 1990;600:649-61; discussion 661-4
pubmed: 1979216
Science. 2009 Oct 9;326(5950):298-301
pubmed: 19815778
Nature. 2002 Jun 27;417(6892):941-4
pubmed: 12068310
Spinal Cord. 2014 Aug;52(8):588-95
pubmed: 24912546
Exp Neurol. 2015 Jul;269:169-87
pubmed: 25900055
Nat Neurosci. 2002 Sep;5(9):861-7
pubmed: 12172551
Hippocampus. 1995;5(6):605-20
pubmed: 8646286
Physiol Rev. 1992 Jan;72(1):165-229
pubmed: 1731370
Nat Rev Neurosci. 2004 Feb;5(2):146-56
pubmed: 14735117
J Neurotrauma. 2007 Oct;24(10):1667-73
pubmed: 17970629
J Comp Neurol. 2003 Aug 4;462(4):431-49
pubmed: 12811811
J Neurosci. 2003 Jan 1;23(1):175-86
pubmed: 12514214
Front Mol Neurosci. 2017 Jul 28;10:228
pubmed: 28804446
Nat Neurosci. 2010 Sep;13(9):1075-81
pubmed: 20694004
Neuron. 2020 Oct 14;108(1):128-144.e9
pubmed: 32810432
Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1499-511
pubmed: 16939971
Exp Neurol. 1975 Sep;48(3 pt. 2):3-15
pubmed: 52554
PLoS One. 2013 Apr 16;8(4):e61878
pubmed: 23613963
Neurosci Lett. 1978 Sep;9(2-3):97-104
pubmed: 19605201
Neural Regen Res. 2022 Jun;17(6):1172-1182
pubmed: 34782551
Nature. 1995 Nov 30;378(6556):498-501
pubmed: 7477407
Cell Transplant. 2021 Jan-Dec;30:963689721989266
pubmed: 33559479
J Neurosci. 2016 Aug 10;36(32):8516-32
pubmed: 27511021
Nat Rev Neurosci. 2012 Feb 15;13(3):183-93
pubmed: 22334213
Nature. 1997 Dec 18-25;390(6661):680-3
pubmed: 9414159
Nature. 2020 May;581(7806):77-82
pubmed: 32376949
Cell. 2018 Jul 26;174(3):521-535.e13
pubmed: 30033363
J Neurosci. 2012 Jun 13;32(24):8208-18
pubmed: 22699902
Science. 2008 Nov 7;322(5903):963-6
pubmed: 18988856
J Neurochem. 2004 Apr;89(1):109-18
pubmed: 15030394
Mol Cell Neurosci. 1999 Feb;13(2):143-66
pubmed: 10192772
Neuron. 2004 Nov 18;44(4):609-21
pubmed: 15541310
Neuron. 2015 Mar 18;85(6):1244-56
pubmed: 25754821
Mol Cell Neurosci. 2003 Mar;22(3):319-30
pubmed: 12691734
Synapse. 2014 Apr;68(4):131-43
pubmed: 24285555
Eur J Neurosci. 2000 Apr;12(4):1165-76
pubmed: 10762348
Neurotherapeutics. 2018 Jul;15(3):541-553
pubmed: 29717413
J Neurosci. 2017 Nov 8;37(45):10808-10816
pubmed: 29118209
Neuron. 2017 Aug 16;95(4):817-833.e4
pubmed: 28817801
Exp Neurol. 2005 May;193(1):29-42
pubmed: 15817262
J Neurosci. 2009 Jun 3;29(22):7116-23
pubmed: 19494134
Life Sci. 2014 Feb 27;97(1):37-44
pubmed: 23892199
Nature. 2001 Jan 18;409(6818):341-6
pubmed: 11201742
Neural Regen Res. 2022 Jan;17(1):85-86
pubmed: 34100432
J Neurosci. 2011 Apr 13;31(15):5605-16
pubmed: 21490201
Nature. 2016 Apr 14;532(7598):195-200
pubmed: 27027288
J Neurosci. 2013 Sep 25;33(39):15350-61
pubmed: 24068802
Exp Neurol. 2020 Jan;323:113089
pubmed: 31697941
Nat Rev Neurosci. 2020 Jul;21(7):366-383
pubmed: 32518349
Brain Res. 1983 Dec 19;289(1-2):205-14
pubmed: 6198035
Neuron. 2002 Jun 13;34(6):885-93
pubmed: 12086637
Int J Biol Sci. 2019 Jun 2;15(7):1557-1570
pubmed: 31337984
J Neurosci. 2011 Oct 5;31(40):14051-66
pubmed: 21976490
J Comp Neurol. 1989 Nov 1;289(1):129-42
pubmed: 2808757
Exp Neurol. 1999 Nov;160(1):51-65
pubmed: 10630190
Science. 2002 Aug 16;297(5584):1190-3
pubmed: 12089450
Front Mol Neurosci. 2015 Aug 07;8:43
pubmed: 26300725
Nat Rev Neurosci. 2006 Aug;7(8):617-27
pubmed: 16858390
Exp Neurol. 2008 Feb;209(2):321-32
pubmed: 17720160
Curr Opin Neurobiol. 2004 Feb;14(1):118-24
pubmed: 15018947
J Neurosci. 2008 Jul 9;28(28):7231-43
pubmed: 18614693
Neuron. 2012 Jun 7;74(5):777-91
pubmed: 22681683
Science. 2004 Aug 6;305(5685):862-5
pubmed: 15297673
Science. 2009 Oct 23;326(5952):592-6
pubmed: 19833921
Neuron. 2002 Jun 13;34(6):895-903
pubmed: 12086638
J Comp Neurol. 1992 Jul 15;321(3):421-41
pubmed: 1506478
Biochem Soc Trans. 2007 Apr;35(Pt 2):207-10
pubmed: 17371239
Exp Neurol. 1995 Aug;134(2):261-72
pubmed: 7556546
J Neurosci. 2015 Oct 14;35(41):13860-7
pubmed: 26468186
Nature. 2002 Apr 11;416(6881):636-40
pubmed: 11948352
Hand Clin. 2013 Aug;29(3):317-30
pubmed: 23895713
Nat Neurosci. 2019 Aug;22(8):1269-1275
pubmed: 31235933
Exp Neurol. 2002 Sep;177(1):265-75
pubmed: 12429228
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6330-4
pubmed: 3862133
Brain Res Bull. 1994;35(5-6):409-12
pubmed: 7859096
Brain Res Rev. 2007 Aug;55(1):17-54
pubmed: 17433836
Mol Cell Neurosci. 2005 Aug;29(4):525-35
pubmed: 15936952
Nature. 1980 Mar 20;284(5753):264-5
pubmed: 7360259
Eur J Neurosci. 2004 Sep;20(5):1161-76
pubmed: 15341588
Brain Res. 2007 Feb 9;1132(1):36-41
pubmed: 17166487
Bone Marrow Transplant. 2007 Oct;40(7):609-19
pubmed: 17603514
Neurosci Res. 2021 Nov 6;:
pubmed: 34748905