Biochemical characterization, cytotoxic, antimutagenic, anticancer and molecular docking studies on
Anticancer
Antimutagenicity
Cytotoxicity
Molecular docking
Phytoconstituents
Tecomella undulata
Journal
Saudi journal of biological sciences
ISSN: 1319-562X
Titre abrégé: Saudi J Biol Sci
Pays: Saudi Arabia
ID NLM: 101543796
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
29
09
2021
revised:
29
10
2021
accepted:
07
12
2021
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
ppublish
Résumé
In this study bioassay-guided screening of Tecomella undulate was performed for its cytotoxic, antimutagenic and anticancer potential. The ariel parts were extracted on a polarity basis (methanol, dichloromethane and hexane). The in vivo toxicity was assessed on Caenorhabditis elegans, and its locomotion was affected by Tecomella undulata hexane (TUAH) the most. Ames test for antimutagenicity showed Tecomella undulata methanol (TUAM) exhibited against mutagen 2AA showed inhibition of 71.03% and 26.32% 2AA in TA98 while in in vitro MTT assay on carcinoma cell lines TUAM showed 68.1% cytotoxicity. Moreover, In resazurin assay on fibroblast cells African green monkey kidney VERO and on the panel of carcinoma cell lines, the most effective extract was TUAM on liver HepG-2 with CC
Identifiants
pubmed: 35531249
doi: 10.1016/j.sjbs.2021.12.015
pii: S1319-562X(21)01048-2
pmc: PMC9072898
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2421-2431Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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