Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium.
acute lymphoblastic leukemia
acute myeloid leukemia
breastfeeding
childhood cancer
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
revised:
11
03
2022
received:
12
01
2022
accepted:
12
04
2022
pubmed:
10
5
2022
medline:
13
8
2022
entrez:
9
5
2022
Statut:
ppublish
Résumé
Increasing evidence suggests that breastfeeding may protect from childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, most studies have limited their analyses to any breastfeeding, and only a few data have examined exclusive breastfeeding, or other exposures such as formula milk. We performed pooled analyses and individual participant data metaanalyses of data from 16 studies (N = 17 189 controls; N = 10 782 ALL and N = 1690 AML cases) from the Childhood Leukemia International Consortium (CLIC) to characterize the associations of breastfeeding duration with ALL and AML, as well as exclusive breastfeeding duration and age at introduction to formula with ALL. In unconditional multivariable logistic regression analyses of pooled data, we observed decreased odds of ALL among children breastfed 4 to 6 months (0.88, 95% CI 0.81-0.96) or 7 to 12 months (OR 0.85, 0.79-0.92). We observed a similar inverse association between breastfeeding ≥4 months and AML (0.82, 95% CI 0.71-0.95). Odds of ALL were reduced among children exclusively breastfed 4 to 6 months (OR 0.73, 95% CI 0.63-0.85) or 7 to 12 months (OR 0.70, 95% CI 0.53-0.92). Random effects metaanalyses produced similar estimates, and findings were unchanged in sensitivity analyses adjusted for race/ethnicity or mode of delivery, restricted to children diagnosed ≥1 year of age or diagnosed with B-ALL. Our pooled analyses indicate that longer breastfeeding is associated with decreased odds of ALL and AML. Few risk factors for ALL and AML have been described, therefore our findings highlight the need to promote breastfeeding for leukemia prevention.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1013-1023Subventions
Organisme : NCI NIH HHS
ID : R03CA132172
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA049450
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA048051
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01ES018172
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01ES009137
Pays : United States
Organisme : NIEHS NIH HHS
ID : R13ES021145
Pays : United States
Organisme : NIEHS NIH HHS
ID : R13ES022868
Pays : United States
Informations de copyright
© 2022 UICC.
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