Chemometrics-assisted development of a validated LC method for simultaneous estimation of temozolomide and γ-linolenic acid: Greenness assessment and application to lipidic nanoparticles.

Chemometrics Chromatography, High Pressure Liquid / methods Liposomes Nanoparticles Reproducibility of Results Temozolomide gamma-Linolenic Acid
Box-Behnken design Chemometrics Forced degradation Green method Lipid nanoparticles Liquid chromatography Simultaneous estimation Stability indicating Temozolamide γ-Linolenic acid

Journal

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Titre abrégé: J Chromatogr B Analyt Technol Biomed Life Sci
Pays: Netherlands
ID NLM: 101139554

Informations de publication

Date de publication:
01 Jun 2022
Historique:
received: 31 03 2022
accepted: 20 04 2022
pubmed: 10 5 2022
medline: 25 5 2022
entrez: 9 5 2022
Statut: ppublish

Résumé

The described work entails the development of a simple, sensitive, green, and robust high-performance liquid chromatographic (HPLC) method for simultaneous estimation of temozolomide (TMZ) and γ-linolenic acid (GLA). The chemometric factor screening study helped identify the critical method parameters optimized using Box-Behnken design for improved understanding and enhancing the method performance. Chromatographic separation was performed on a Kinetex® C

Identifiants

DOI: 10.1016/j.jchromb.2022.123261 PMID: 35533423
pubmed: 35533423
pii: S1570-0232(22)00165-9
doi: 10.1016/j.jchromb.2022.123261
pii:
doi:

Substances chimiques

Lipid Nanoparticles 0
Liposomes 0
gamma-Linolenic Acid 78YC2MAX4O
Temozolomide YF1K15M17Y

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

123261

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Sarwar Beg (S)

School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi 110062, India. Electronic address: sbeg4@uclan.ac.uk.

Sagar S Panda (SS)

Department of Pharmaceutical Analysis and Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, Ganjam, Odisha 760010, India.

Kamalinder K Singh (KK)

School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom; UCLan Centre of Smart Materials, University of Central Lancshire, Preston PR1 2HE, United Kingdom. Electronic address: KSingh1@uclan.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Chimiométrie › Chemometrics-assisted development of a...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Chemometrics-assisted development of a...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Chemometrics-assisted development of a...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Chemometrics-assisted development of a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Chemometrics-assisted development of a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Dacarbazine › Témozolomide › Chemometrics-assisted development of a...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Acide gamma linolénique › Chemometrics-assisted development of a...