Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice.
IFN-γ
Pinworm
Th2
Treg
Trichuris muris
Wild mice
Journal
International journal for parasitology
ISSN: 1879-0135
Titre abrégé: Int J Parasitol
Pays: England
ID NLM: 0314024
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
12
12
2021
revised:
25
03
2022
accepted:
30
03
2022
pubmed:
10
5
2022
medline:
7
7
2022
entrez:
9
5
2022
Statut:
ppublish
Résumé
Infections with high doses of intestinal nematodes result in protective immunity based on robust type 2 responses in most mouse lines under laboratory conditions. Here, we report on cellular responses of wild house mice from northern Germany. We detected robust Th1 responses in wild house mice naturally infected with the whipworm Trichuris muris. In contrast, mice infected with pinworms (Syphacia, Aspiculuris) reported type-2 activity by elevated IgG1 levels and eosinophil counts, but also harbored high frequencies of Foxp3+ regulatory T cells, suggesting that natural whip- and pinworm infections induce distinct immunoregulatory as well as effector profiles.
Identifiants
pubmed: 35533731
pii: S0020-7519(22)00080-7
doi: 10.1016/j.ijpara.2022.03.006
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
519-524Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.