Endothelial glycocalyx integrity in oncological patients.

Cardiotoxicity / pathology Glycocalyx Humans Microvessels Pulse Wave Analysis Vascular Stiffness
Cancer Cardiotoxicity Endothelial function Glycocalyx

Journal

International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291

Informations de publication

Date de publication:
01 08 2022
Historique:
received: 16 01 2022
revised: 23 03 2022
accepted: 04 05 2022
pubmed: 10 5 2022
medline: 9 6 2022
entrez: 9 5 2022
Statut: ppublish

Résumé

Cancer is associated with early changes in the cardiovascular system (CV) before overt cardiotoxicity. Endothelial dysfunction is induced by chemotherapeutic regimens but there is no data for endothelial glycocalyx in cancer. Sixty-four patients with cancer (65.6% with solid tumors and 34.4% with hematological malignancies) and 32 controls from the outpatient cardiology clinic were included in the study. The perfused boundary region (PBR) of the sublingual arterial microvessels, Pulse Wave Velocity (PWV) and augmentation index (AI) were measured. A standard transthoracic echocardiogram plus assessment of global longitudinal strain (GLS) of all cardiac chambers were performed. There was no difference in the baseline profile (age, sex, smoking, hypertension, diabetes, hyperlipidemia and coronary artery disease) and in the echocardiographic parameters between the two groups, with the exception of left atrial volume (33.3 ± 13 in cancer patients vs 27.6 ± 6.5 ml/m Endothelial function as assessed by endothelial glycocalyx thickness is significantly impaired in cancer patients without overt cardiotoxicity. This implies that PBR might be useful for the early assessment of microvascular and endothelial toxicity of cancer.

Sections du résumé

BACKGROUND
Cancer is associated with early changes in the cardiovascular system (CV) before overt cardiotoxicity. Endothelial dysfunction is induced by chemotherapeutic regimens but there is no data for endothelial glycocalyx in cancer.
METHODS
Sixty-four patients with cancer (65.6% with solid tumors and 34.4% with hematological malignancies) and 32 controls from the outpatient cardiology clinic were included in the study. The perfused boundary region (PBR) of the sublingual arterial microvessels, Pulse Wave Velocity (PWV) and augmentation index (AI) were measured. A standard transthoracic echocardiogram plus assessment of global longitudinal strain (GLS) of all cardiac chambers were performed.
RESULTS
There was no difference in the baseline profile (age, sex, smoking, hypertension, diabetes, hyperlipidemia and coronary artery disease) and in the echocardiographic parameters between the two groups, with the exception of left atrial volume (33.3 ± 13 in cancer patients vs 27.6 ± 6.5 ml/m
CONCLUSIONS
Endothelial function as assessed by endothelial glycocalyx thickness is significantly impaired in cancer patients without overt cardiotoxicity. This implies that PBR might be useful for the early assessment of microvascular and endothelial toxicity of cancer.

Identifiants

DOI: 10.1016/j.ijcard.2022.05.010 PMID: 35533752
pubmed: 35533752
pii: S0167-5273(22)00661-1
doi: 10.1016/j.ijcard.2022.05.010
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

62-67

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Kalliopi Keramida (K)

2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Cardiology Department, General Anti-Cancer, Oncological Hospital, Agios Savvas, Athens, Greece.

John Thymis (J)

2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Maria Anastasiou (M)

Section of Medical Oncology, Second Propaedeutic Department of Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Konstantinos Katogiannis (K)

2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Ioannis Kotsantis (I)

Section of Medical Oncology, Second Propaedeutic Department of Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Panagiota Economopoulou (P)

Section of Medical Oncology, Second Propaedeutic Department of Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Vassiliki Pappa (V)

Hematology Division, Second Propaedeutic Department of Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Panagiotis Tsirigotis (P)

Hematology Division, Second Propaedeutic Department of Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Vasiliki Bistola (V)

2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Maria Thodi (M)

2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Amanda Psyrri (A)

Section of Medical Oncology, Second Propaedeutic Department of Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Gerasimos Filippatos (G)

2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: gfilippatos@gmail.com.

Ignatios Ikonomidis (I)

2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Rayonnement › Cardiotoxicité › Endothelial glycocalyx integrity in...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Glycocalyx › Endothelial glycocalyx integrity in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Endothelial glycocalyx integrity in...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Microvaisseaux › Endothelial glycocalyx integrity in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Analyse de l'onde de pouls › Endothelial glycocalyx integrity in...
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