Imaging, quantitation and kinetic modelling of intravitreal nanomaterials.
Drug delivery
Intravitreal
Liposome
Modelling
Pharmacokinetics
Polymeric micelle
Retina
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
10 Jun 2022
10 Jun 2022
Historique:
received:
01
02
2022
revised:
15
04
2022
accepted:
30
04
2022
pubmed:
10
5
2022
medline:
7
6
2022
entrez:
9
5
2022
Statut:
ppublish
Résumé
In this study, the intravitreal pharmacokinetics of nanomaterials were investigated in vivo in rats and rabbits. Impact of particle size and shape (spherical, longitudinal) on ocular particle distribution and elimination was investigated with fundus camera, optical coherence tomography and ocular fluorophotometry. Differently sized particles showed prolonged ocular retention and remarkable differences in vitreal elimination, but size dependence was consistent, suggesting that other features have influence on their vitreal kinetics. We also demonstrate that liposomes are eliminated from the rabbit vitreous mainly via the anterior route. Simulation of drug concentrations after injection of intravitreal particles shows the importance of synchronized particle retention and drug release rate for efficient drug delivery. In conclusion, we provide kinetic insights in intravitreally administered nanoparticles to improve retinal drug delivery.
Identifiants
pubmed: 35533923
pii: S0378-5173(22)00355-6
doi: 10.1016/j.ijpharm.2022.121800
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121800Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.