Retinol-binding protein 2 (RBP2): More than just dietary retinoid uptake.
2-monoacylglycerol
All-trans-retinoic acid
CRBP2
Cellular retinol-binding protein 2
Glucose-dependent insulinotropic polypeptide (GIP)
Incretin
Obesity
RBP2
Retinoids
Retinol-binding proteins
Vitamin A
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
28
12
2021
revised:
28
03
2022
accepted:
22
04
2022
pubmed:
10
5
2022
medline:
3
6
2022
entrez:
9
5
2022
Statut:
ppublish
Résumé
Retinol-binding protein 2 (RBP2, also known as cellular retinol-binding protein 2 (CRBP2)) is a member of the fatty acid-binding protein family and has been extensively studied for its role in facilitating dietary vitamin A (retinol) uptake and metabolism within enterocytes of the small intestine. RBP2 is present in highest concentrations in the proximal small intestine where it constitutes approximately 0.1-0.5% of soluble protein. Recent reports have established that RBP2 binds monoacylglycerols (MAGs) with high affinity, including the canonical endocannabinoid 2-arachidonoylglycerol (2-AG). Crystallographic studies reveal that retinol, 2-AG, or other long-chain MAGs alternatively can bind in the retinol-binding pocket of RBP2. It also has been demonstrated recently that Rbp2-deficient mice are more susceptible to developing obesity and associated metabolic phenotypes when exposed to a high fat diet, or as they age when fed a conventional chow diet. When subjected to an oral fat challenge, the Rbp2-deficient mice release into the circulation significantly more, compared to littermate controls, of the intestinal hormone glucose-dependent insulinotropic polypeptide (GIP). These new findings regarding RBP2 structure and actions within the intestine are the focus of this review.
Identifiants
pubmed: 35533980
pii: S1388-1981(22)00069-5
doi: 10.1016/j.bbalip.2022.159179
pmc: PMC9191623
mid: NIHMS1811154
pii:
doi:
Substances chimiques
Monoglycerides
0
Retinoids
0
Retinol-Binding Proteins, Cellular
0
Vitamin A
11103-57-4
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
159179Subventions
Organisme : NIAAA NIH HHS
ID : R21 AA028110
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK132710
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY023948
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122071
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK068437
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Références
J Biol Chem. 2016 Apr 15;291(16):8528-40
pubmed: 26900151
J Biol Chem. 1987 Apr 15;262(11):5428-30
pubmed: 3549720
Int J Mol Med. 2015 Mar;35(3):724-30
pubmed: 25585692
Subcell Biochem. 2016;81:21-76
pubmed: 27830500
J Phys Chem Lett. 2019 Dec 5;10(23):7333-7339
pubmed: 31714784
Pharmacol Ther. 2017 May;173:19-33
pubmed: 28132904
J Biol Chem. 1988 Apr 25;263(12):5815-9
pubmed: 3281948
Cell Metab. 2013 Apr 2;17(4):475-90
pubmed: 23562074
Nat Rev Endocrinol. 2015 Oct;11(10):592-605
pubmed: 26260145
Annu Rev Med. 2022 Jan 27;73:439-453
pubmed: 34669431
J Biol Chem. 2012 Jan 27;287(5):3415-24
pubmed: 22170058
J Biol Chem. 2008 May 16;283(20):13510-9
pubmed: 18348983
Biochemistry. 1993 Jan 26;32(3):872-8
pubmed: 8422392
Crit Rev Biochem Mol Biol. 2020 Apr;55(2):197-218
pubmed: 32466661
Sci Adv. 2020 Mar 11;6(11):eaay8937
pubmed: 32195347
Annu Rev Nutr. 2008;28:73-95
pubmed: 18435590
Eur J Endocrinol. 2021 Aug 03;185(3):R75-R91
pubmed: 34260412
Am J Physiol. 1996 Aug;271(2 Pt 1):G347-56
pubmed: 8770051
J Biol Chem. 2010 Oct 22;285(43):32679-32683
pubmed: 20716527
J Biol Chem. 2002 Sep 27;277(39):36617-23
pubmed: 12138113
J Mol Biol. 2000 Jul 14;300(3):619-32
pubmed: 10884357
J Biol Chem. 1986 Jun 25;261(18):8218-23
pubmed: 2424895
J Lipid Res. 2013 Jul;54(7):1761-75
pubmed: 23440512
J Biol Chem. 2015 Apr 3;290(14):8711-21
pubmed: 25666611
J Mol Biol. 1993 Apr 20;230(4):1247-59
pubmed: 8487303
Annu Rev Pathol. 2011;6:345-64
pubmed: 21073338
J Mol Biol. 1999 Mar 5;286(4):1179-95
pubmed: 10047490
J Lipid Res. 2002 Nov;43(11):1773-808
pubmed: 12401878
Biochim Biophys Acta. 1993 Feb 13;1156(2):223-31
pubmed: 8427880
J Lipid Res. 2021;62:100054
pubmed: 33631211
Nutr Rev. 1994 Feb;52(2 Pt 2):S24-31
pubmed: 8202279
Biofactors. 2014 Jul-Aug;40(4):389-97
pubmed: 24752980
EMBO J. 1988 Jun;7(6):1597-604
pubmed: 2458918
J Biol Chem. 1984 Feb 10;259(3):1476-82
pubmed: 6537950
ACS Chem Biol. 2019 Mar 15;14(3):434-448
pubmed: 30721022
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6375-80
pubmed: 19307565
Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3226-32
pubmed: 25478840
J Biol Chem. 2013 Jul 5;288(27):19805-15
pubmed: 23658011
Am J Pathol. 2012 Mar;180(3):984-997
pubmed: 22222225