Effect of antibiotics in the first week of life on faecal microbiota development.
Epidemiology
Gastroenterology
Infant Development
Microbiology
Neonatology
Journal
Archives of disease in childhood. Fetal and neonatal edition
ISSN: 1468-2052
Titre abrégé: Arch Dis Child Fetal Neonatal Ed
Pays: England
ID NLM: 9501297
Informations de publication
Date de publication:
09 May 2022
09 May 2022
Historique:
received:
18
08
2021
accepted:
17
03
2022
entrez:
9
5
2022
pubmed:
10
5
2022
medline:
10
5
2022
Statut:
aheadofprint
Résumé
Infants are frequently exposed to antibiotics (AB) in the first week of life for suspected bacterial infections. Little is known about the effect of AB on the developing intestinal microbiota. Therefore, we studied intestinal microbiota development with and without AB exposure in the first week of life in term born infants. We analysed the faecal microbiota from birth until 2.5 years of age by 16S rRNA gene amplicon sequencing in a cohort with 56 term born infants, exposed to AB in the first week of life (AB+) (AB for 2-3 days (AB2, n=20), AB for 7 days (AB7, n=36)), compared with 126 healthy controls (AB-). The effects of AB and duration were examined in relation to delivery and feeding mode. AB+ was associated with significantly increased relative abundance of AB exposure in the first week of life alters faecal microbiota development with deviations in the relative abundance of individual taxa until 1 year of age. These alterations can have long-term health consequences, which emphasises the need for future studies aiming at restoring intestinal microbiota after AB administration.
Sections du résumé
BACKGROUND
BACKGROUND
Infants are frequently exposed to antibiotics (AB) in the first week of life for suspected bacterial infections. Little is known about the effect of AB on the developing intestinal microbiota. Therefore, we studied intestinal microbiota development with and without AB exposure in the first week of life in term born infants.
METHODS
METHODS
We analysed the faecal microbiota from birth until 2.5 years of age by 16S rRNA gene amplicon sequencing in a cohort with 56 term born infants, exposed to AB in the first week of life (AB+) (AB for 2-3 days (AB2, n=20), AB for 7 days (AB7, n=36)), compared with 126 healthy controls (AB-). The effects of AB and duration were examined in relation to delivery and feeding mode.
RESULTS
RESULTS
AB+ was associated with significantly increased relative abundance of
CONCLUSIONS
CONCLUSIONS
AB exposure in the first week of life alters faecal microbiota development with deviations in the relative abundance of individual taxa until 1 year of age. These alterations can have long-term health consequences, which emphasises the need for future studies aiming at restoring intestinal microbiota after AB administration.
Identifiants
pubmed: 35534183
pii: archdischild-2021-322861
doi: 10.1136/archdischild-2021-322861
pmc: PMC9606546
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: This work and the PhD research by EVD was financed by a EU Joint Programming Initiative namely A Healthy Diet for a Healthy Life (JPIHDHL, http://www.healthydietforhealthylife.eu/) inconjunction with ZonMW and Danone Nutricia Research. GH is a full full-time employee of Chr Hansen A/S since January 2020. CB received a grant financed by JPI HDHL inconjunction with ZonMW and Danone Nutricia Research. RMvE was an employee at Danone Nutricia Research till 2020. JK is a full-time employee of Danone Nutricia.
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