Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature.
Journal
Case reports in hematology
ISSN: 2090-6560
Titre abrégé: Case Rep Hematol
Pays: United States
ID NLM: 101576456
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
01
2022
accepted:
14
03
2022
entrez:
10
5
2022
pubmed:
11
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. MTX-associated LPD (MTX-LPD) includes a spectrum of lymphocytic proliferations, ranging from polyclonal hyperplasia to malignant lymphoma. MTX-LPD diagnosis can be challenging, as signs and symptoms are often nonspecific and may overlap with those of several other conditions, including exacerbation of the underlying autoimmune disease. Spontaneous regression of LPD after MTX discontinuation is characteristic of MTX-LPD, therefore avoiding chemotherapeutic intervention in a significant proportion of patients. Other cases, however, should receive chemotherapy.
Identifiants
pubmed: 35535243
doi: 10.1155/2022/7178065
pmc: PMC9078817
doi:
Types de publication
Case Reports
Langues
eng
Pagination
7178065Informations de copyright
Copyright © 2022 Carolina Afonso et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
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