An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections.

Animals Antifungal Agents / chemistry Cell-Penetrating Peptides / pharmacology Drug Resistance, Fungal Fungi Invasive Fungal Infections / drug therapy Mammals Polymers / pharmacology

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
26 05 2022
Historique:
pubmed: 11 5 2022
medline: 28 5 2022
entrez: 10 5 2022
Statut: ppublish

Résumé

The high mortality rate of invasive fungal infections and quick emergence of drug-resistant fungal pathogens urgently call for potent antifungal agents. Inspired by the cell penetrating peptide (CPP) octaarginine (R8), we elongated to 28 residues poly(d,l-homoarginine) to obtain potent toxicity against both fungi and mammalian cells. Further incorporation of glutamic acid residues shields positive charge density and introduces partial zwitterions in the obtained optimal peptide polymer that displays potent antifungal activity against drug-resistant fungi superior to antifungal drugs, excellent stability upon heating and UV exposure, negligible

Identifiants

DOI: 10.1021/acs.jmedchem.2c00274 PMID: 35535860
pubmed: 35535860
doi: 10.1021/acs.jmedchem.2c00274
doi:

Substances chimiques

Antifungal Agents 0
Cell-Penetrating Peptides 0
Polymers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7296-7311

Auteurs

Yueming Wu (Y)

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0001-7668-7409

Weinan Jiang (W)

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0001-5393-5713

Zihao Cong (Z)

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0003-3462-7373

Kang Chen (K)

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Yunrui She (Y)

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Chao Zhong (C)

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Wenjing Zhang (W)

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0002-6076-8017

Minzhang Chen (M)

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0002-5377-7732

Min Zhou (M)

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0002-0444-0324

Ning Shao (N)

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

Guohui Xiao (G)

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Xiaoyan Shao (X)

Shanghai Ruijin Rehabilitation Hospital, Shanghai 200023, China.
ORCID: 0000-0002-3839-1241

Yidong Dai (Y)

Shanghai Ruijin Rehabilitation Hospital, Shanghai 200023, China.
ORCID: 0000-0002-0556-795X

Jian Fei (J)

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
ORCID: 0000-0001-7159-8562

Gonghua Song (G)

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0002-4673-6561

Runhui Liu (R)

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
ORCID: 0000-0002-7699-086X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An Effective Strategy to Develop Potent and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › An Effective Strategy to Develop Potent and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides de pénétration cellulaire › An Effective Strategy to Develop Potent and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance des champignons aux médicaments › An Effective Strategy to Develop Potent and...
questionsmedicales.fr › Eucaryotes › Champignons › An Effective Strategy to Develop Potent and...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Mycoses › Infections fongiques invasives › An Effective Strategy to Develop Potent and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › An Effective Strategy to Develop Potent and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › An Effective Strategy to Develop Potent and...