Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions.
SOX/miRNA interplay
dysregulation of miRNA expression
glioblastoma
gliogenesis
glioma stem cells
ischemic stroke
neural stem cells
neural tissue regeneration
neurodegenerative diseases
neurodevelopment
neurogenesis
traumatic brain injury
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
entrez:
10
5
2022
pubmed:
11
5
2022
medline:
11
5
2022
Statut:
ppublish
Résumé
Precise tuning of gene expression, accomplished by regulatory networks of transcription factors, epigenetic modifiers, and microRNAs, is crucial for the proper neural development and function of the brain cells. The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis, such as maintaining the cell stemness, cell proliferation, cell fate decisions, and terminal differentiation into neurons and glial cells. MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression. Together with other gene regulatory factors, microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment. The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain. Deregulated SOX/microRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies, including neurodegenerative disorders, traumatic brain injury, and cancer. Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neurorestoration. Numerous studies have confirmed complex interactions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma. Keeping in mind the crucial roles of SOX genes and microRNAs in neural development, we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions. Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.
Identifiants
pubmed: 35535866
pii: NeuralRegenRes_2022_17_11_2325_338990
doi: 10.4103/1673-5374.338990
pmc: PMC9120710
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2325-2334Déclaration de conflit d'intérêts
None
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