The endogenous progenitor response following traumatic brain injury: a target for cell therapy paradigms.
cell therapy
endogenous repair
neurogenic niche
progenitors
traumatic brain injury
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
entrez:
10
5
2022
pubmed:
11
5
2022
medline:
11
5
2022
Statut:
ppublish
Résumé
Although there is ample evidence that central nervous system progenitor pools respond to traumatic brain injury, the reported effects are variable and likely contribute to both recovery as well as pathophysiology. Through a better understanding of the diverse progenitor populations in the adult brain and their niche-specific reactions to traumatic insult, treatments can be tailored to enhance the benefits and dampen the deleterious effects of this response. This review provides an overview of endogenous precursors, the associated effects on cognitive recovery, and the potential of exogenous cell therapeutics to modulate these endogenous repair mechanisms. Beyond the hippocampal dentate gyrus and subventricular zone of the lateral ventricles, more recently identified sites of adult neurogenesis, the meninges, as well as circumventricular organs, are also discussed as targets for endogenous repair. Importantly, this review highlights that progenitor proliferation alone is no longer a meaningful outcome and studies must strive to better characterize precursor spatial localization, transcriptional profile, morphology, and functional synaptic integration. With improved insight and a more targeted approach, the stimulation of endogenous neurogenesis remains a promising strategy for recovery following traumatic brain injury.
Identifiants
pubmed: 35535870
pii: NeuralRegenRes_2022_17_11_2351_335833
doi: 10.4103/1673-5374.335833
pmc: PMC9120693
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2351-2354Déclaration de conflit d'intérêts
None
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