Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies.
HMPV
inclusion bodies
phase separation
pneumovirus
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
pubmed:
11
5
2022
medline:
1
7
2022
entrez:
10
5
2022
Statut:
ppublish
Résumé
Human metapneumovirus (HMPV) inclusion bodies (IBs) are dynamic structures required for efficient viral replication and transcription. The minimum components needed to form IB-like structures in cells are the nucleoprotein (N) and the tetrameric phosphoprotein (P). HMPV P binds to the following two versions of the N protein in infected cells: N-terminal P residues interact with monomeric N (N
Identifiants
pubmed: 35536005
doi: 10.1128/mbio.01099-22
pmc: PMC9239117
doi:
Substances chimiques
Antiviral Agents
0
Nucleic Acids
0
Nucleoproteins
0
Phosphoproteins
0
RNA
63231-63-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0109922Subventions
Organisme : NIAID NIH HHS
ID : P01 AI120943
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123926
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI161374
Pays : United States
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