Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription.
Epigenetics
Memory
Neuroscience
Pharmacology
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
15 06 2022
15 06 2022
Historique:
received:
08
03
2021
accepted:
05
05
2022
pubmed:
11
5
2022
medline:
18
6
2022
entrez:
10
5
2022
Statut:
ppublish
Résumé
Caffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippocampus at the epigenomic, proteomic, and metabolomic levels. Caffeine lowered metabolism-related processes (e.g., at the level of metabolomics and gene expression) in bulk tissue, while it induced neuron-specific epigenetic changes at synaptic transmission/plasticity-related genes and increased experience-driven transcriptional activity. Altogether, these findings suggest that regular caffeine intake improves the signal-to-noise ratio during information encoding, in part through fine-tuning of metabolic genes, while boosting the salience of information processing during learning in neuronal circuits.
Identifiants
pubmed: 35536645
pii: 149371
doi: 10.1172/JCI149371
pmc: PMC9197525
doi:
pii:
Substances chimiques
Caffeine
3G6A5W338E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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