Can't smell the virus: SARS-CoV-2, chromatin organization, and anosmia.

Anosmia COVID-19 Chromatin / genetics Humans SARS-CoV-2 / genetics Smell

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
09 05 2022
Historique:
entrez: 10 5 2022
pubmed: 11 5 2022
medline: 14 5 2022
Statut: ppublish

Résumé

Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans, but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell-autonomous disruption of long-range genomic interactions of olfactory receptor genes in response to SARS-CoV-2 infection, and these interactions remain disrupted long after virus clearance.

Identifiants

DOI: 10.1016/j.devcel.2022.04.015 PMID: 35537401 PMC: PMC9082776
pubmed: 35537401
pii: S1534-5807(22)00272-6
doi: 10.1016/j.devcel.2022.04.015
pmc: PMC9082776
pii:
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1081-1082

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

EMBO Rep. 2022 Sep 5;23(9):e55101
pubmed: 35972201
Nature. 2020 Jul;583(7818):834-838
pubmed: 32408338
Cell. 2022 Mar 17;185(6):1052-1064.e12
pubmed: 35180380
Neuron. 2000 Sep;27(3):487-97
pubmed: 11055432
Br J Pharmacol. 2020 Nov;177(21):4851-4865
pubmed: 32462701
Curr Opin Genet Dev. 2022 Feb;72:101-109
pubmed: 34896807
ACS Chem Neurosci. 2020 Jun 3;11(11):1555-1562
pubmed: 32379417

Auteurs

Matan Sorek (M)

Department of Genetics, The Alexander Silberman Institute for Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel; The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.

Eran Meshorer (E)

Department of Genetics, The Alexander Silberman Institute for Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel; The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel. Electronic address: eran.meshorer@mail.huji.ac.il.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'olfaction › Anosmie › Can't smell the virus: SARS-CoV-2, chromatin...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Can't smell the virus: SARS-CoV-2, chromatin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Can't smell the virus: SARS-CoV-2, chromatin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Can't smell the virus: SARS-CoV-2, chromatin...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Can't smell the virus: SARS-CoV-2, chromatin...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Odorat › Can't smell the virus: SARS-CoV-2, chromatin...