COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI - the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases.
COVID-19
autoimmune diseases
biological therapy
familial Mediterranean fever
Journal
RMD open
ISSN: 2056-5933
Titre abrégé: RMD Open
Pays: England
ID NLM: 101662038
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
27
10
2021
accepted:
04
02
2022
entrez:
10
5
2022
pubmed:
11
5
2022
medline:
14
5
2022
Statut:
ppublish
Résumé
There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared. A national multicentric prospective cohort study was conducted from the French Rheumatic and Musculoskeletal Diseases (RMD) COVID-19 cohort. Patients with SAID were matched with patients with non-SAID on age±7 years, gender and number of comorbidities to consider important confounding factors. Impact of SAID on severity of SARS-CoV-2 infection was analysed using multinomial logistic regression for severity in three classes (mild, moderate and severe with mild status as reference). Fine-Gray regression model for length of hospital stay and binomial logistic regression model for risk of death at 30 days. We identified 117 patients with SAID (sex ratio 0.84, 17 children) and compared them with 1545 patients with non-autoinflammatory immune-mediated inflammatory disorders (non-SAID). 67 patients had a monogenic SAID (64 with familial Mediterranean fever). Other SAIDs were Behçet' disease (n=21), undifferentiated SAID (n=16), adult-onset Still disease (n=9) and systemic-onset juvenile idiopathic arthritis (n=5). Ten adults developed severe form (8.6%). Six patients died. All children had a benign disease. After matching on age±7 years, sex and number of comorbidities, no significant difference between the two groups in length of stay and the severity of infection was noted. As identified in the whole French RMD COVID-19 cohort, patients with SAID on corticosteroids and with multiple comorbidities are prone to develop more severe COVID-19 forms.
Identifiants
pubmed: 35537796
pii: rmdopen-2021-002063
doi: 10.1136/rmdopen-2021-002063
pmc: PMC9091487
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Florence Aeschlimann
(F)
Christian Agard
(C)
Nassim Ait-Abdallah
(N)
Jean-David Albert
(JD)
Didier Alcaix
(D)
Jean-Sébastien Allain
(JS)
Yannick Allanore
(Y)
Zahir Amoura
(Z)
Adamah Amouzougan
(A)
Emma Andre
(E)
Anaïs Arbault
(A)
Jean-Benoît Arlet
(JB)
Laurent Arnaud
(L)
Denis Arniaud
(D)
Herliette Arty-Hue
(H)
Lucie Atlan
(L)
Alexandra Audemard-Verger Tours
(AA)
Christine Audoin-Pajot
(C)
Victor Audren
(V)
Gilles Avenel
(G)
Jérôme Avouac
(J)
Maxime Bach-Bunner
(M)
Hélène Bacquet-Deschryver
(H)
Brigitte Bader-Meunier
(B)
Nathalie Balandraud
(N)
Jean-Charles Balblanc
(JC)
Claire Ballot-Schmit
(C)
Stéphane Bally
(S)
Frédéric Banal
(F)
Béatrice Banneville
(B)
Pierre Barbery
(P)
Audrey Barrelet
(A)
Géraldine Bart
(G)
André Basch
(A)
Vincent Baumier
(V)
Guillaume Bayer
(G)
Sophie Bayle
(S)
Catherine Beauvais
(C)
Rudie Beinat
(R)
Véronique Belin
(V)
Rakiba Belkhir
(R)
Alexandre Belot
(A)
Aurélie Beltai
(A)
Ruben Benainous
(R)
Mohammed Benammar
(M)
Chahinez Bendahmane
(C)
Mathilde Benhamou
(M)
Ygal Benhamou
(Y)
Ahmed Benmansour
(A)
Pascal Bennet
(P)
Brigitte Bernoux-Manat
(B)
Elise Berthet
(E)
Sabine Berthier
(S)
Olivia Berthoud
(O)
Emilie Berthoux
(E)
Ewa Bertolini
(E)
Adrien Bigot
(A)
Aurélia Bisson-Vaivre
(A)
Gilles Blaison
(G)
Gilles Bolla
(G)
Olivier Bonidan
(O)
Christine Bonnet
(C)
Raphaël Borie
(R)
Charlotte Borocco
(C)
Marie Bossert
(M)
Laurence Boudou
(L)
Françoise Bouhour
(F)
Kévin Bouiller
(K)
Laurence Bouillet
(L)
Bastien Bouldoires
(B)
Thomas Bourree
(T)
Ines Boussen
(I)
Karima Boussoualim
(K)
Eric Bouvard
(E)
Brondino Regine
(B)
Pierre Buchlin
(P)
Laurence Cabantous
(L)
Patrice Cacoub
(P)
Simon Cadiou
(S)
Alaine Cantagrel
(A)
Didier Caplanne
(D)
Aurélia Carbasse
(A)
Maurizio Carteni
(M)
Brice Castel
(B)
Pascal Cathebras
(P)
Hervé Caumont
(H)
Audrey Cayot-Bouillet
(A)
Annalisa Celant
(A)
Aurélie Chaffin
(A)
Benjamin Chaigne
(B)
Benoît Chaillous
(B)
Romuald Champy
(R)
Agnès Charcot
(A)
Pierre Charles
(P)
Isabelle Charlot-Lambrecht
(I)
Caroline Charpin
(C)
Emmanuel Chatelus
(E)
Bernard Chaudier
(B)
Pascal Chazerain
(P)
Pascale Chertok
(P)
Xavier Chevalier
(X)
Maxime Chevreau
(M)
Emilie Chotard
(E)
Ewa Bertolini
(E)
Adrien Bigot
(A)
Aurélia Bisson-Vaivre
(A)
Gilles Blaison
(G)
Gilles Bolla
(G)
Olivier Bonidan
(O)
Christine Bonnet
(C)
Raphaël Borie
(R)
Charlotte Borocco
(C)
Marie Bossert
(M)
Laurence Boudou
(L)
Françoise Bouhour
(F)
Kévin Bouiller
(K)
Laurence Bouillet
(L)
Bastien Bouldoires
(B)
Thomas Bourree
(T)
Ines Boussen
(I)
Karima Boussoualim
(K)
Eric Bouvard
(E)
Brondino Regine
(B)
Pierre Buchlin
(P)
Laurence Cabantous
(L)
Patrice Cacoub
(P)
Simon Cadiou
(S)
Alaine Cantagrel
(A)
Didier Caplanne
(D)
Aurélia Carbasse
(A)
Maurizio Carteni
(M)
Brice Castel
(B)
Pascal Cathebras
(P)
Hervé Caumont
(H)
Audrey Cayot-Bouillet
(A)
Annalisa Celant
(A)
Aurélie Chaffin
(A)
Benjamin Chaigne
(B)
Benoît Chaillous
(B)
Romuald Champy
(R)
Agnès Charcot
(A)
Pierre Charles
(P)
Isabelle Charlot-Lambrecht
(I)
Caroline Charpin
(C)
Emmanuel Chatelus
(E)
Bernard Chaudier
(B)
Pascal Chazerain
(P)
Pascale Chertok
(P)
Xavier Chevalier
(X)
Maxime Chevreau
(M)
Emilie Chotard
(E)
Delphine Chu Miow Lin
(DCM)
Pascal Claudepierre
(P)
Gaëlle Clavel
(G)
Cyril Clavel-Osorio
(C)
Marine Clay
(M)
Johanna Clet
(J)
Fleur Cohen
(F)
Gregory Cohen
(G)
Marie-Eve Colette-Cedoz
(ME)
Nived Collercandy
(N)
Antoine Colombey
(A)
Chloé Comarmond
(C)
Bernard Combe
(B)
Céline Comparon
(C)
Elodie Constant
(E)
Arnaud Constantin
(A)
Pascal Coquerelle
(P)
Justine Corli
(J)
Clémence Corre
(C)
Nathalie Costedoat-Chalumeau
(N)
Marion Couderc
(M)
Marie Couret
(M)
Fabienne Coury-Lucas
(F)
Cécile Coutarel
(C)
Fabrice Coutier
(F)
Richard Damade
(R)
Laurence Daver-Malaterre
(L)
Claire De Moreuil
(C)
Marijke Decrock
(M)
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(M)
Emilie Delattre Barrois
(ED)
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(C)
Delphine Denarie
(D)
Amélie Denis
(A)
Camille Deprouw
(C)
Emanuelle Dernis
(E)
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(A)
Renaud Desbarbieux
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(J)
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(M)
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(F)
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(V)
Mathilde Devaux
(M)
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(R)
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(Y)
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(E)
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(G)
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(DD)
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(JJ)
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(C)
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(A)
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(C)
Cécile Dumaine
(C)
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(AE)
Chantal Dumoulin-Richez
(C)
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(A)
Géraldine Durand
(G)
Mariane Durandin-Truffinet
(M)
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(PM)
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(S)
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(M)
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(M)
Esther Ebstein
(E)
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(A)
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(SE)
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(S)
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(R)
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(P)
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(C)
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(S)
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(D)
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(D)
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(M)
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(M)
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(B)
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(J)
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(R)
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(N)
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(E)
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(A)
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(F)
René-Marc Flipo
(RM)
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(E)
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(AC)
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(A)
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(C)
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(H)
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(L)
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(ML)
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(P)
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(A)
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(J)
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(FF)
Laurence Gagneux-Lemoussu
(L)
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(MG)
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(J)
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(F)
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(A)
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(N)
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(T)
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(JF)
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(R)
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(P)
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(V)
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(M)
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(L)
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(D)
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(S)
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(N)
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(E)
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(C)
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(E)
Ghislaine Gill
(G)
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(J)
Mélanie Gilson
(M)
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(P)
Jeanine-Sophie Giraudet-Le Quintrec
(JG)
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(A)
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(B)
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(C)
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(B)
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(B)
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(S)
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(F)
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(M)
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Ambre Hittinger-Roux
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(PA)
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(SB)
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(A)
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(JP)
Augustin Latourte
(A)
Christian Lavigne
(C)
Noémie Le Gouellec
(NL)
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(SLG)
Guillaume Le Guenno
(GL)
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Emmanuel Ledoult
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Diane Leguy
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Olivier Leloire
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Marie Leroy-Gouix
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Charles Leske
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(T)
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(A)
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(CL)
François-Xavier Limbach
(FX)
Frédéric Liote
(F)
Anne Lohse
(A)
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(P)
Charlotte Lucas
(C)
Etienne Mabrut
(E)
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(A)
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(N)
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(M)
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(H)
Thibault Maillet
(T)
François Maillot
(F)
Sandrine Malochet-Guinamand
(S)
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(Q)
Julie Mankikian
(J)
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(S)
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(N)
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(T)
Alexandre Maria
(A)
Xavier Mariette
(X)
Hubert Marotte
(H)
Claire Martin
(C)
Thierry Martin
(T)
Alexis Mathian
(A)
François Maurier
(F)
Frédéric Maury
(F)
Betty Mazet-Guillaume
(B)
Arnaud Mazouyez
(A)
Hassan Mazyad
(H)
Nadia Mehsen-Cetre
(N)
Arsène Mekinian
(A)
Isabelle Melki
(I)
Jean-Camille Meric
(JC)
Laurent Messer
(L)
Martin Michaud
(M)
Catherine Michel
(C)
Matthias Michel
(M)
Mathilde Michon
(M)
Anne-Marie Milesi-Lecat
(AM)
Anna Molto
(A)
Olivier Moranne
(O)
Gautier Morel
(G)
Hugo Morel
(H)
Jacques Morel
(J)
Franck Morin
(F)
Laurence Moulinier
(L)
Guillaume Moulis
(G)
Bertrand Moura
(B)
Claudine Naude
(C)
Minh Nguyen
(M)
Sabine Nicolas-Vullierme
(S)
Hubert Nielly
(H)
Gaétane Nocturne
(G)
Aurore Nottez
(A)
Henri-Olivier Ollagnon
(HO)
Eric Oziol
(E)
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(I)
Guillaume Padern
(G)
Anne Pagnier
(A)
Caroline Paris
(C)
Antoine Parrot
(A)
Tristan Pascart
(T)
Yasmina Pascaud-Mansour
(Y)
Lætitia Paulin
(L)
Stephan Pavy
(S)
Judith Payet
(J)
Laurent Perard
(L)
Céline Pereira-Gillion
(C)
Yves-Marie Pers
(YM)
Edouard Pertuiset
(E)
Micheline Pha
(M)
Thao Pham
(T)
Maud Pichon
(M)
Audrey Pierreisnard
(A)
Gabrielle Pizana
(G)
Sylvaine Poignant
(S)
Elsa Poix
(E)
Agnès Portier
(A)
Jacques Pouchot
(J)
Antoine Poulet
(A)
Nicolas Poursac
(N)
Grégory Pugnet
(G)
Déborah Puyraimond-Zemmour
(D)
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(P)
Quenet Marion
(Q)
Viviane Queyrel
(V)
Loïc Raffray
(L)
Jérôme Razanamahery
(J)
Philippe Remy
(P)
Myriam Renard
(M)
Jessica Rene
(J)
Sabine Revuz
(S)
Bénédicte Rey
(B)
Gaëlle Richard-Colmant
(G)
Olivier Richer
(O)
Christophe Richez
(C)
Elodie Riviere
(E)
Etienne Riviere
(E)
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(S)
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(S)
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(J)
Isabelle Roitg
(I)
Michel Rolland
(M)
Mélanie Roriz
(M)
Carole Rosenberg
(C)
Linda Rossi
(L)
Olivier Roth
(O)
Sid-Ahmed Rouidi
(SA)
Mathilde Roumier
(M)
Mickaël Rousiere
(M)
Clémentine Ousselin
(C)
Bénédicte Rouviere
(B)
Christian Roux
(C)
Fabienne Roux
(F)
Marielle Roux
(M)
Nicolas Roux
(N)
Diane Rouzaud
(D)
Sylvie Rozenberg
(S)
Ruyssen-Witrand Adeline
(RW)
Sacco Isabelle
(S)
Sadji Fatiha
(S)
Laurent Sailler
(L)
Carine Salliot
(C)
Jean-Hugues Salmon
(JH)
Charlotte Samaille
(C)
Maxime Samson
(M)
Alain Saraux
(A)
Léa Savey
(L)
Jean Schmidt
(J)
Julie Seguier
(J)
Jérémie Sellam
(J)
Eric Senbel
(E)
Thomas Sene
(T)
Patricia Senet
(P)
Raphaële Seror
(R)
Amélie Servettaz
(A)
Pascal Seve
(P)
Aurélie Sicaud
(A)
Nadia Sivova
(N)
Smets Vincent Sobanski
(SV)
Christelle Sordet
(C)
Elisabeth Sornay-Rendu
(E)
Martin Soubrier
(M)
Odile Souchaud-Debouverie
(O)
Gaëlle Sourisseau-Diverres
(G)
Lætitia Sparsa
(L)
Lionel Spielmann
(L)
Chloé Stavris
(C)
Sarah Steib
(S)
Catherine Straus
(C)
Victor Strotz
(V)
Sylvain Mathieu
(S)
Séverine Taffignon-Clave
(S)
Déborah Talmud
(D)
Chloé Taraud
(C)
Nora Tenenbaum
(N)
Claire Theillac
(C)
None Thomachot
Thierry Thomas
(T)
Nathalie Tieulie
(N)
Soizic Tiriau
(S)
Alice Tison
(A)
Anne Tournadre
(A)
Eric Toussirot
(E)
Ludovic Trefond
(L)
Sophie Trijau
(S)
Sébastien Trouillier
(S)
Anne-Priscille Trouvin
(AP)
Marie-Elise Truchetet
(ME)
Florence Uettwiller
(F)
Florence Ulrich
(F)
Yurdagul Uzunhan
(Y)
Isabelle Valls-Bellec
(I)
Jacques Vaquier
(J)
Eric Veillard
(E)
Laurent Veillon
(L)
Guillaume Vial
(G)
Jean-François Viallard
(JF)
Judith Victor
(J)
Claire Vidon
(C)
Vidon Camille Vigne
(VC)
Alexandre Virone
(A)
Ursula Warzocha
(U)
Daniel Wendling
(D)
Claude Werle
(C)
Cécile Wibaux
(C)
Michel Wisniewski
(M)
Juliette Woessner
(J)
Bernadette Xerri-Campano
(B)
Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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