Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis.
COVID-19
SARS-CoV-2
adverse effects
lipid nanoparticle
mRNA vaccine
spike protein
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
13
02
2022
revised:
27
03
2022
accepted:
08
04
2022
pubmed:
11
5
2022
medline:
29
6
2022
entrez:
10
5
2022
Statut:
ppublish
Résumé
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19) pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is undoubtedly saving thousands of lives. However, adverse effects (AEs) following vaccination have been noted which may relate to a proinflammatory action of the lipid nanoparticles used or the delivered mRNA (i.e., the vaccine formulation), as well as to the unique nature, expression pattern, binding profile, and proinflammatory effects of the produced antigens - spike (S) protein and/or its subunits/peptide fragments - in human tissues or organs. Current knowledge on this topic originates mostly from cell-based assays or from model organisms; further research on the cellular/molecular basis of the mRNA vaccine-induced AEs will therefore promise safety, maintain trust, and direct health policies.
Identifiants
pubmed: 35537987
pii: S1471-4914(22)00103-4
doi: 10.1016/j.molmed.2022.04.007
pmc: PMC9021367
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Lipid Nanoparticles
0
Liposomes
0
RNA, Messenger
0
Spike Glycoprotein, Coronavirus
0
Vaccines, Synthetic
0
Viral Vaccines
0
mRNA Vaccines
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
542-554Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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