Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
11 05 2022
11 05 2022
Historique:
received:
15
07
2021
accepted:
28
04
2022
revised:
10
04
2022
entrez:
10
5
2022
pubmed:
11
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
The family of hexokinases (HKs) catalyzes the first step of glycolysis, the ATP-dependent phosphorylation of glucose to glucose-6-phosphate. While HK1 and HK2 are ubiquitously expressed, the less well-studied HK3 is primarily expressed in hematopoietic cells and tissues and is highly upregulated during terminal differentiation of some acute myeloid leukemia (AML) cell line models. Here we show that expression of HK3 is predominantly originating from myeloid cells and that the upregulation of this glycolytic enzyme is not restricted to differentiation of leukemic cells but also occurs during ex vivo myeloid differentiation of healthy CD34
Identifiants
pubmed: 35538058
doi: 10.1038/s41419-022-04891-w
pii: 10.1038/s41419-022-04891-w
pmc: PMC9091226
doi:
Substances chimiques
Hexokinase
EC 2.7.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
448Informations de copyright
© 2022. The Author(s).
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