Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
11 Nov 2019
11 Nov 2019
Historique:
received:
06
09
2019
accepted:
04
11
2019
entrez:
11
5
2022
pubmed:
11
11
2019
medline:
11
11
2019
Statut:
epublish
Résumé
Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated novel dipeptidyl nitrile based cysteine protease inhibitors (Neq0551, Neq0554 and Neq0568) into biocompatible apoferritin (AFt) protein nanocages to achieve specific delivery to tumours and pH-induced drug release. AFt-encapsulated Neq0554 demonstrated ∼3-fold enhanced
Identifiants
pubmed: 35539052
doi: 10.1039/c9ra07161j
pii: c9ra07161j
pmc: PMC9075514
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36699-36706Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
All the authors confirm there are no conflicts to declare.
Références
Int J Pharm. 2017 Feb 25;518(1-2):281-288
pubmed: 28017769
Genes Dev. 2006 Mar 1;20(5):543-56
pubmed: 16481467
Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8
pubmed: 18226527
Pharmacol Ther. 2015 Nov;155:105-16
pubmed: 26299995
Biotech Histochem. 2004 Jun-Aug;79(3-4):121-7
pubmed: 15621884
Adv Healthc Mater. 2015 Dec 30;4(18):2816-21
pubmed: 26592186
Nat Rev Cancer. 2013 May;13(5):342-55
pubmed: 23594855
Nat Rev Cancer. 2006 Oct;6(10):764-75
pubmed: 16990854
Cell. 2011 Oct 14;147(2):275-92
pubmed: 22000009
Exp Parasitol. 2019 May;200:84-91
pubmed: 30954455
Small. 2009 Aug 3;5(15):1738-41
pubmed: 19360723
Clin Exp Metastasis. 2013 Oct;30(7):891-902
pubmed: 23748470
Nat Protoc. 2006;1(5):2315-9
pubmed: 17406473
PLoS One. 2012;7(12):e49635
pubmed: 23272048
PLoS One. 2015 Apr 30;10(4):e0120348
pubmed: 25927437
Mol Microbiol. 2006 Aug;61(3):655-74
pubmed: 16803590
Invest New Drugs. 2014 Oct;32(5):838-50
pubmed: 24927857
PLoS Negl Trop Dis. 2015 Jul 14;9(7):e0003916
pubmed: 26173110
ACS Nano. 2013 Jun 25;7(6):4830-7
pubmed: 23718215
World J Gastroenterol. 2014 Dec 14;20(46):17532-40
pubmed: 25516668
Sci Rep. 2014 Apr 15;4:4698
pubmed: 24732136
Biochim Biophys Acta. 2012 Mar;1820(3):291-317
pubmed: 21851850
Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15;303(8):G894-903
pubmed: 22899821
Biochim Biophys Acta Proteins Proteom. 2017 Oct;1865(10):1267-1273
pubmed: 28739445
Trends Pharmacol Sci. 2008 Jan;29(1):22-8
pubmed: 18037508
Biochim Biophys Acta. 2012 Jan;1824(1):68-88
pubmed: 22024571
J Physiol Pharmacol. 2017 Apr;68(2):165-174
pubmed: 28614765
Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13408-13421
pubmed: 27539547
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
Cancer Cell. 2004 May;5(5):443-53
pubmed: 15144952
Int J Cancer. 1983 Jan 15;31(1):111-7
pubmed: 6299970
Biochimie. 2016 Mar;122:208-18
pubmed: 26343556
J Am Chem Soc. 2013 Oct 2;135(39):14726-30
pubmed: 23971698
Anticancer Agents Med Chem. 2019;19(1):112-120
pubmed: 30370859
PLoS One. 2010 Sep 22;5(9):e12894
pubmed: 20877570
Cancer Cell Int. 2016 May 26;16:39
pubmed: 27231438
Eur J Cancer. 2000 Apr;36(6):787-95
pubmed: 10762753
Nat Rev Cancer. 2007 Oct;7(10):800-8
pubmed: 17851543
Artif Cells Nanomed Biotechnol. 2018;46(sup3):S847-S854
pubmed: 30449179
J Control Release. 2005 Nov 28;108(2-3):193-214
pubmed: 16246446
Nat Rev Drug Discov. 2010 Sep;9(9):690-701
pubmed: 20811381
Chem Commun (Camb). 2007 Sep 7;(33):3453-5
pubmed: 17700879
ACS Appl Mater Interfaces. 2016 Jun 15;8(23):14430-41
pubmed: 27219717
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14900-5
pubmed: 25267615
Chem Rev. 1997 Feb 5;97(1):133-172
pubmed: 11848867