A strained alkyne-containing bipyridine reagent; synthesis, reactivity and fluorescence properties.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
04 Nov 2019
04 Nov 2019
Historique:
received:
29
08
2019
accepted:
29
10
2019
entrez:
11
5
2022
pubmed:
6
11
2019
medline:
6
11
2019
Statut:
epublish
Résumé
We report the synthesis of a bipyridyl reagent containing a strained alkyne, which significantly restricts its flexibility. Upon strain-promoted alkyne-azide cycloaddition (SPAAC) with an azide, which does not require a Cu catalyst, the structure becomes significantly more flexible and an increase in fluorescence is observed. Upon addition of Zn(ii), the fluorescence is enhanced further. The reagent has the potential to act as a fluorescent labelling agent with azide-containing substrates, including biological molecules.
Identifiants
pubmed: 35540623
doi: 10.1039/c9ra06866j
pii: c9ra06866j
pmc: PMC9074932
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36154-36161Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare no conflicting interests.
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