Synthesis, cytotoxicity and anti-inflammatory activity of rhamnose-containing ursolic and betulinic acid saponins.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
02 Dec 2019
02 Dec 2019
Historique:
received:
20
09
2019
accepted:
25
11
2019
entrez:
11
5
2022
pubmed:
2
12
2019
medline:
2
12
2019
Statut:
epublish
Résumé
Betulinic acid and ursolic acid are ubiquitous, naturally-occurring triterpenoids exhibiting various pharmacological activities including cytotoxic and anti-inflammatory activities. However, these triterpenoids display unfavorable pharmacokinetic properties as well as low aqueous solubility. It has been shown that the presence of α-l-rhamnose moieties positively modulates the anticancer activity of secondary metabolites. Herein we report the synthesis and
Identifiants
pubmed: 35541393
doi: 10.1039/c9ra09389c
pii: c9ra09389c
pmc: PMC9076072
doi:
Types de publication
Journal Article
Langues
eng
Pagination
39743-39757Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
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