Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
06 05 2022
06 05 2022
Historique:
entrez:
11
5
2022
pubmed:
12
5
2022
medline:
18
5
2022
Statut:
ppublish
Résumé
Protozoan parasites that infect humans are widespread and lead to varied clinical manifestations, including life-threatening illnesses in immunocompromised individuals. Animal models have provided insight into innate immunity against parasitic infections; however, species-specific differences and complexity of innate immune responses make translation to humans challenging. Thus, there is a need for in vitro systems that can elucidate mechanisms of immune control and parasite dissemination. We have developed a human microphysiological system of intestinal tissue to evaluate parasite-immune-specific interactions during infection, which integrates primary intestinal epithelial cells and immune cells to investigate the role of innate immune cells during epithelial infection by the protozoan parasite,
Identifiants
pubmed: 35544643
doi: 10.1126/sciadv.abm8012
pmc: PMC9075809
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabm8012Subventions
Organisme : NCI NIH HHS
ID : R01 CA205101
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125498
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI144016
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA185747
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211082
Pays : United States
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