Immunity to enteric viruses.
COVID-19
Mucosal immunology
T cells
adaptive immunity
enteric viruses
innate immunity
norovirus
poliovirus
rotations
viruses
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
10 05 2022
10 05 2022
Historique:
received:
10
03
2022
revised:
04
04
2022
accepted:
11
04
2022
entrez:
11
5
2022
pubmed:
12
5
2022
medline:
18
5
2022
Statut:
ppublish
Résumé
Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among children in developing countries. The host response to enteric viruses occurs primarily within the mucosa, where the intestinal immune system must balance protection against pathogens with tissue protection and tolerance to harmless commensal bacteria and food. Here, we summarize current knowledge in natural immunity to enteric viruses, highlighting specialized features of the intestinal immune system. We further discuss how knowledge of intestinal anti-viral mechanisms can be translated into vaccine development with particular focus on immunization in the oral route. Research reveals that the intestine is a complex interface between enteric viruses and the host where environmental factors influence susceptibility and immunity to infection, while viral infections can have lasting implications for host health. A deeper mechanistic understanding of enteric anti-viral immunity with this broader context can ultimately lead to better vaccines for existing and emerging viruses.
Identifiants
pubmed: 35545029
pii: S1074-7613(22)00178-9
doi: 10.1016/j.immuni.2022.04.007
pmc: PMC9257994
mid: NIHMS1799040
pii:
doi:
Substances chimiques
Antigens, Viral
0
Vaccines
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
800-818Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK093674
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113375
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
J Infect Dis. 1990 Dec;162(6):1291-7
pubmed: 2172403
Nat Immunol. 2021 Apr;22(4):449-459
pubmed: 33686285
J Virol. 2011 Mar;85(5):1970-9
pubmed: 21177809
Science. 2010 Apr 2;328(5974):102-6
pubmed: 20360110
Microbes Infect. 2001 Nov;3(13):1145-56
pubmed: 11709295
Lancet Infect Dis. 2018 Nov;18(11):1211-1228
pubmed: 30243583
J Virol. 2013 Dec;87(23):12685-93
pubmed: 24049163
Lancet. 2010 Aug 21;376(9741):615-23
pubmed: 20692031
J Infect Dis. 1988 Jul;158(1):160-5
pubmed: 2839578
J Infect Dis. 2016 Jun 15;213(12):1996-2004
pubmed: 26908751
Lancet Gastroenterol Hepatol. 2020 May;5(5):434-435
pubmed: 32199469
Science. 2015 Jan 16;347(6219):269-73
pubmed: 25431489
Nature. 2019 May;569(7754):126-130
pubmed: 30988509
Monogr Ser World Health Organ. 1968;57:3-329
pubmed: 4976616
N Engl J Med. 2006 Jan 5;354(1):23-33
pubmed: 16394299
J Clin Immunol. 2010 Jan;30(1):10-6
pubmed: 20101521
Adv Life Course Res. 2010 Dec 1;15(4):132-146
pubmed: 21516232
J Infect Dis. 2014 Sep 15;210(6):853-64
pubmed: 24688069
Nat Rev Immunol. 2019 Oct;19(10):614-625
pubmed: 31201377
Microbiol Immunol. 1996;40(2):161-8
pubmed: 8867613
N Engl J Med. 2010 Jan 28;362(4):289-98
pubmed: 20107214
J Virol. 2007 Feb;81(4):1796-812
pubmed: 17121790
J Virol. 2017 Mar 13;91(7):
pubmed: 28077655
Lancet. 2007 Nov 24;370(9601):1757-63
pubmed: 18037080
Cell. 2020 Nov 12;183(4):1070-1085.e12
pubmed: 33031744
Am J Gastroenterol. 2006 Oct;101(10):2333-40
pubmed: 17032199
Science. 2006 Nov 17;314(5802):1157-60
pubmed: 17110582
Cell Mol Immunol. 2016 Nov;13(6):862-870
pubmed: 26277894
J Infect Dis. 2020 Sep 1;222(7):1076-1083
pubmed: 32249284
Vaccine. 2014 Aug 11;32 Suppl 1:A110-6
pubmed: 25091663
Pediatr Infect Dis J. 2015 Jan;34(1):115-6
pubmed: 25741808
Vaccine. 2020 Feb 24;38(9):2250-2257
pubmed: 31767462
Vaccine. 2014 Aug 11;32 Suppl 1:A134-9
pubmed: 25091668
Blood. 2005 Jul 15;106(2):593-600
pubmed: 15827133
J Virol. 1999 Jun;73(6):4533-5
pubmed: 10233910
Nat Rev Gastroenterol Hepatol. 2021 Apr;18(4):269-283
pubmed: 33589829
Vaccine. 2004 Feb 25;22(8):984-90
pubmed: 15161075
Hum Vaccin. 2010 Jul;6(7):532-42
pubmed: 20622508
Viruses. 2018 Jan 20;10(1):
pubmed: 29361691
Clin Exp Immunol. 2014 Mar;175(3):468-75
pubmed: 24237035
Immunology. 2012 Jan;135(1):19-26
pubmed: 22044118
Nature. 2014 Dec 4;516(7529):94-8
pubmed: 25409145
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):951-5
pubmed: 1846972
Clin Microbiol Infect. 2022 Feb;28(2):304.e1-304.e3
pubmed: 34763059
Infect Immun. 1997 Apr;65(4):1387-94
pubmed: 9119478
Rev Infect Dis. 1984 May-Jun;6 Suppl 2:S413-8
pubmed: 6740083
Science. 2010 Jun 25;328(5986):1705-9
pubmed: 20576892
Vaccine. 2016 Jun 8;34(27):3068-3075
pubmed: 27154394
Science. 2014 Nov 14;346(6211):861-5
pubmed: 25395539
Infect Immun. 1983 Feb;39(2):917-27
pubmed: 6299952
N Engl J Med. 2011 Dec 8;365(23):2178-87
pubmed: 22150036
Curr Opin Infect Dis. 2011 Oct;24(5):496-502
pubmed: 21734569
Nat Med. 2003 May;9(5):548-53
pubmed: 12692541
J Virol. 1972 Nov;10(5):1075-81
pubmed: 4117963
Infect Immun. 1998 Dec;66(12):5889-96
pubmed: 9826370
Nat Commun. 2015 May 19;6:7090
pubmed: 25987506
Gastroenterology. 2021 Apr;160(5):1647-1661
pubmed: 33307034
Innate Immun. 2015 May;21(4):416-28
pubmed: 25213347
Science. 2011 Oct 14;334(6053):249-52
pubmed: 21998395
Science. 2017 Apr 7;356(6333):44-50
pubmed: 28386004
J Virol. 1990 Sep;64(9):4375-82
pubmed: 1974652
J Pediatric Infect Dis Soc. 2022 Apr 30;11(4):149-158
pubmed: 34904636
Expert Rev Mol Med. 2014 Mar 10;16:e5
pubmed: 24606759
Nat Med. 2005 Apr;11(4 Suppl):S45-53
pubmed: 15812489
BMJ Glob Health. 2019 Aug 20;4(4):e001633
pubmed: 31544903
Cladistics. 2020 Aug;36(4):358-373
pubmed: 34618969
Cell Host Microbe. 2018 Nov 14;24(5):677-688.e5
pubmed: 30392830
Infect Immun. 2001 Jun;69(6):4125-8
pubmed: 11349086
J Virol. 2005 May;79(10):5988-95
pubmed: 15857985
Sci Transl Med. 2013 Jul 10;5(193):193ra91
pubmed: 23843452
Allergy. 2022 Jan;77(1):304-307
pubmed: 34543444
PLoS Pathog. 2011 Jul;7(7):e1002115
pubmed: 21779163
Immunity. 2009 Apr 17;30(4):556-65
pubmed: 19362020
Viruses. 2011 Dec;3(12):2462-77
pubmed: 22355449
Sci Transl Med. 2021 Jan 20;13(577):
pubmed: 33288662
Science. 1997 Feb 28;275(5304):1320-3
pubmed: 9036860
J Virol. 2008 Jul;82(14):6812-9
pubmed: 18480435
J Infect Dis. 2020 Feb 3;221(4):561-565
pubmed: 31565733
Proc Soc Exp Biol Med. 1953 Dec;84(3):570-3
pubmed: 13134217
Immunity. 2004 Oct;21(4):527-38
pubmed: 15485630
Lancet Infect Dis. 2016 Dec;16(12):1377-1384
pubmed: 27638357
J Infect Dis. 2014 Jul 15;210(2):171-82
pubmed: 24436449
Science. 2003 Mar 7;299(5612):1575-8
pubmed: 12624267
Immunity. 2014 Feb 20;40(2):248-61
pubmed: 24462723
Biochem Pharmacol. 2021 Jan;183:114316
pubmed: 33152343
Mucosal Immunol. 2022 Jan;15(1):1-9
pubmed: 34239028
Virology. 1995 Aug 20;211(2):474-80
pubmed: 7645251
J Clin Invest. 2011 Aug;121(8):3051-61
pubmed: 21737878
Immunity. 2022 Jul 12;55(7):1234-1249.e6
pubmed: 35617965
J Immunol. 2018 Sep 15;201(6):1615-1624
pubmed: 30181300
Science. 2005 Jan 14;307(5707):254-8
pubmed: 15653504
Front Pharmacol. 2021 Oct 25;12:718484
pubmed: 34759819
Virology. 2014 Mar;452-453:191-201
pubmed: 24606696
N Engl J Med. 2006 Jan 5;354(1):11-22
pubmed: 16394298
J Virol. 2008 Jul;82(13):6610-7
pubmed: 18417579
Annu Rev Virol. 2019 Sep 29;6(1):177-197
pubmed: 31283442
Sci Rep. 2016 Nov 24;6:37295
pubmed: 27881837
Vaccine. 2018 Jun 27;36(28):4134-4141
pubmed: 29801999
Immunity. 2010 Mar 26;32(3):305-15
pubmed: 20346772
PLoS Pathog. 2008 Dec;4(12):e1000236
pubmed: 19079577
J Virol. 2013 Jun;87(12):7015-31
pubmed: 23596300
Clin Microbiol Rev. 2014 Jul;27(3):441-62
pubmed: 24982316
Nat Rev Immunol. 2011 Jun 17;11(7):445-56
pubmed: 21681197
Nat Biotechnol. 2013 Jul;31(7):623-9
pubmed: 23748502
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
J Infect. 2020 Aug;81(2):183-189
pubmed: 32360880
J Infect Dis. 2014 Nov 1;210 Suppl 1:S380-9
pubmed: 25316859
Sci Transl Med. 2021 Jan 20;13(577):
pubmed: 33288661
PLoS Pathog. 2012;8(5):e1002670
pubmed: 22570612
BMJ Glob Health. 2019 Aug 28;4(4):e001613
pubmed: 31543993
N Engl J Med. 2020 Mar 5;382(10):929-936
pubmed: 32004427
J Exp Med. 2013 Aug 26;210(9):1871-88
pubmed: 23960190
PLoS Pathog. 2013;9(9):e1003592
pubmed: 24039576
Adv Virus Res. 2008;71:1-50
pubmed: 18585526
Immunity. 2016 Mar 15;44(3):647-658
pubmed: 26944199
Microbiol Immunol. 1990;34(8):683-9
pubmed: 2280725
Microbiol Immunol. 1984;28(6):679-90
pubmed: 6090870
Hum Vaccin Immunother. 2014;10(2):505-11
pubmed: 24240068
Immunity. 2020 Nov 17;53(5):1001-1014.e20
pubmed: 33022229
Lab Anim Sci. 1987 Feb;37(1):55-7
pubmed: 3586604
Microbiol Immunol. 1992;36(6):623-31
pubmed: 1522811
J Gen Virol. 2013 Aug;94(Pt 8):1761-1768
pubmed: 23636823
J Gen Virol. 2006 Nov;87(Pt 11):3393-3396
pubmed: 17030875
Sci Rep. 2017 Mar 30;7:45559
pubmed: 28358023
Nat Microbiol. 2017 Dec;2(12):1586-1591
pubmed: 29109476
Cell. 2019 Oct 17;179(3):644-658.e13
pubmed: 31607511
Vaccine. 2013 Jun 19;31(28):2963-71
pubmed: 23623865
Nat Microbiol. 2019 Jul;4(7):1120-1128
pubmed: 30936486
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Clin Exp Immunol. 2002 Mar;127(3):495-8
pubmed: 11966766
J Virol. 2014 Jun;88(12):6934-43
pubmed: 24696493
J Virol. 2015 Oct 07;90(1):43-56
pubmed: 26446608
Immunity. 2011 May 27;34(5):637-50
pubmed: 21616434
Lancet. 2016 Sep 24;388(10051):1291-301
pubmed: 27673470
Invest Ophthalmol Vis Sci. 1978 Jul;17(7):705-9
pubmed: 669902
Nature. 2021 Mar;591(7850):458-463
pubmed: 33536617
Clin Infect Dis. 2016 Jan 15;62(2):157-65
pubmed: 26400993
J Clin Microbiol. 1988 Apr;26(4):732-8
pubmed: 2835391
Trends Microbiol. 1996 Oct;4(10):394-400
pubmed: 8899965
Pediatr Infect Dis J. 2009 Mar;28(3 Suppl):S54-6
pubmed: 19252424
PLoS Pathog. 2008 Jul 18;4(7):e1000108
pubmed: 18636103
J Virol. 2011 Aug;85(16):8316-27
pubmed: 21653670
JCI Insight. 2018 Jul 12;3(13):
pubmed: 29997294
Nat Commun. 2020 Jun 11;11(1):2968
pubmed: 32528015
J Nutr. 2009 Nov;139(11):2154S-218S
pubmed: 19793845
Cell Host Microbe. 2014 Jan 15;15(1):36-46
pubmed: 24439896
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17264-9
pubmed: 15563593
Future Microbiol. 2015;10(5):791-808
pubmed: 25824845
Nat Immunol. 2001 Apr;2(4):361-7
pubmed: 11276208
BMC Pediatr. 2014 Nov 30;14:295
pubmed: 25433534
Mucosal Immunol. 2008 May;1(3):183-97
pubmed: 19079178
Int Immunol. 1999 Feb;11(2):191-8
pubmed: 10069417
Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:517-540
pubmed: 32466690
Front Immunol. 2019 Jul 02;10:1499
pubmed: 31312204
PLoS Pathog. 2012;8(4):e1002599
pubmed: 22532797
J Exp Med. 2017 May 1;214(5):1211-1226
pubmed: 28432200
Cell. 2010 Jun 25;141(7):1135-45
pubmed: 20602997
Vaccine. 2010 Feb 3;28(5):1226-33
pubmed: 19945415
Curr Opin Immunol. 2020 Feb;62:45-53
pubmed: 31874430
Trends Mol Med. 2016 Dec;22(12):1047-1059
pubmed: 27887808
J Gen Virol. 2014 Aug;95(Pt 8):1668-1676
pubmed: 24784416
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
J Immunol. 1999 Apr 15;162(8):5011-8
pubmed: 10202050
Mucosal Immunol. 2016 Nov;9(6):1559-1570
pubmed: 27007673
Expert Rev Vaccines. 2020 Jun;19(6):585-593
pubmed: 32543244
Eur J Immunol. 2005 Jul;35(7):2122-30
pubmed: 15948217
Nat Immunol. 2004 Jul;5(7):730-7
pubmed: 15208624
J Immunol. 2002 Mar 1;168(5):2173-81
pubmed: 11859103
Lancet. 1973 Dec 8;2(7841):1281-3
pubmed: 4127639
Mucosal Immunol. 2016 Jan;9(1):68-82
pubmed: 25899688
Future Microbiol. 2018 Jan;13:97-118
pubmed: 29218997
Mucosal Immunol. 2018 Jul;11(4):1254-1264
pubmed: 29467446
Elife. 2021 Aug 12;10:
pubmed: 34382937
J Virol. 2012 Dec;86(24):13515-23
pubmed: 23035219
Clin Infect Dis. 2015 Apr 1;60(7):1057-64
pubmed: 25550350
Trends Immunol. 2018 Apr;39(4):264-275
pubmed: 29221933
J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S821-S828
pubmed: 34550392
J Clin Invest. 1997 Mar 15;99(6):1281-6
pubmed: 9077537
Lancet Glob Health. 2020 Feb;8(2):e215-e224
pubmed: 31981554
Nat Immunol. 2021 Feb;22(2):216-228
pubmed: 33462454
Clin Infect Dis. 2007 Nov 1;45(9):1120-31
pubmed: 17918073
Clin Gastroenterol Hepatol. 2007 Apr;5(4):457-60
pubmed: 17289440
MMWR Morb Mortal Wkly Rep. 2020 Jun 26;69(25):784-789
pubmed: 32584798
Proc Soc Exp Biol Med. 1954 Jan;85(1):183-8
pubmed: 13134329
Front Immunol. 2014 Apr 23;5:182
pubmed: 24795724
Infect Immun. 1982 Nov;38(2):755-63
pubmed: 6292110
Proc Jpn Acad Ser B Phys Biol Sci. 2007 Dec;83(8):266-75
pubmed: 24367151
Immunity. 2007 Sep;27(3):370-83
pubmed: 17892846
Clin Infect Dis. 2016 Jan 15;62(2):150-6
pubmed: 26349548
J Exp Med. 2010 Nov 22;207(12):2703-17
pubmed: 20975040
Vaccine. 2021 May 21;39(22):2989-2994
pubmed: 33933314
Immunity. 2006 Sep;25(3):373-81
pubmed: 16979569
Lancet. 2010 Aug 21;376(9741):606-14
pubmed: 20692030
J Virol. 1986 Dec;60(3):1068-74
pubmed: 3023659
J Virol. 1995 Dec;69(12):7800-6
pubmed: 7494291
Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):11875-11877
pubmed: 32404416
Nat Microbiol. 2019 Nov;4(11):1778-1780
pubmed: 31358983
Am J Gastroenterol. 2020 May;115(5):766-773
pubmed: 32287140
Am J Epidemiol. 1988 Sep;128(3):615-28
pubmed: 2843039
Front Immunol. 2020 Feb 18;11:211
pubmed: 32133002
J Immunol. 1995 Sep 15;155(6):2877-87
pubmed: 7673704
Lancet Infect Dis. 2017 Aug;17(8):843-853
pubmed: 28483414
Annu Rev Immunol. 2010;28:243-73
pubmed: 20192805
J Immunol. 1998 Oct 15;161(8):4227-35
pubmed: 9780197
Expert Rev Vaccines. 2009 Dec;8(12):1627-41
pubmed: 19943758
PLoS Pathog. 2008 Jun 06;4(6):e1000082
pubmed: 18535656
Science. 2015 Jan 16;347(6219):266-9
pubmed: 25431490
Front Immunol. 2019 May 29;10:1158
pubmed: 31191533
Curr Opin Gastroenterol. 2014 Jan;30(1):25-33
pubmed: 24232370
Mucosal Immunol. 2018 Sep;11(5):1281-1289
pubmed: 29674648
Eur J Immunol. 2015 Oct;45(10):2742-57
pubmed: 26256101
Cell. 1989 Mar 10;56(5):855-65
pubmed: 2538245
Lancet Glob Health. 2020 Sep;8(9):e1195-e1202
pubmed: 32827481
Emerg Infect Dis. 2013 Aug;19(8):1260-7
pubmed: 23876612
Virology. 1997 Nov 24;238(2):169-79
pubmed: 9400590
Lancet. 1973 Dec 29;2(7844):1497
pubmed: 4129337
PLoS One. 2012;7(10):e48224
pubmed: 23118957
Vaccine. 2002 Nov 22;21(1-2):138-45
pubmed: 12443672
J Virol. 1997 Jan;71(1):479-86
pubmed: 8985374
Cell. 2017 Nov 2;171(4):783-794.e13
pubmed: 28942917
Elife. 2022 Feb 09;11:
pubmed: 35137688
Clin Immunol. 2003 Sep;108(3):241-7
pubmed: 14499247
Curr Opin Virol. 2012 Aug;2(4):419-25
pubmed: 22677178
J Infect Dis. 2010 Oct 15;202(8):1212-8
pubmed: 20815703
N Engl J Med. 2009 Oct 29;361(18):1776-85
pubmed: 19864676
Science. 1994 Jun 24;264(5167):1918-21
pubmed: 8009221
J Infect Dis. 2022 Jan 5;225(1):34-41
pubmed: 34758086
N Engl J Med. 2011 Jul 28;365(4):337-46
pubmed: 21793745
J Exp Med. 1991 Feb 1;173(2):471-81
pubmed: 1824857
Immunity. 2017 Oct 17;47(4):723-738.e5
pubmed: 29031786
Expert Rev Vaccines. 2017 Oct;16(10):987-995
pubmed: 28832219
Ann N Y Acad Sci. 1995 May 31;754:97-107
pubmed: 7625685
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11284-8
pubmed: 7479980
Nat Rev Immunol. 2014 Oct;14(10):667-85
pubmed: 25234148
Sci Immunol. 2018 Feb 9;3(20):
pubmed: 29440266
Nature. 2017 Jun 29;546(7660):667-670
pubmed: 28636595
Mucosal Immunol. 2012 Nov;5(6):712-9
pubmed: 22739233
FEBS Lett. 2020 Jun;594(12):1918-1946
pubmed: 31944286
Nature. 2008 Oct 2;455(7213):674-8
pubmed: 18724357
Viral Immunol. 2009 Jun;22(3):189-94
pubmed: 19435415
Clin Vaccine Immunol. 2013 Jan;20(1):85-94
pubmed: 23155123
J Exp Med. 2016 Jan 11;213(1):53-73
pubmed: 26712806
Science. 2020 Jul 3;369(6499):50-54
pubmed: 32358202
Lancet Infect Dis. 2020 Apr;20(4):435-444
pubmed: 31978354
Nature. 2011 Jul 17;475(7357):514-8
pubmed: 21765430
J Infect Dis. 1997 Feb;175 Suppl 1:S228-34
pubmed: 9203721
Jpn J Microbiol. 1966 Jul;10(2):115-25
pubmed: 4961228
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Lancet. 2018 Jul 14;392(10142):175-186
pubmed: 30025810
J Infect Dis. 2000 Dec;182(6):1602-9
pubmed: 11069230
Br Med J. 1976 Apr 3;1(6013):812
pubmed: 1260345
Vaccines (Basel). 2020 Jul 23;8(3):
pubmed: 32718082
J Clin Invest. 2000 Dec;106(12):1541-52
pubmed: 11120761
JAMA. 1991 Nov 20;266(19):2724-9
pubmed: 1942425
J Infect Dis. 1996 Sep;174 Suppl 1:S107-11
pubmed: 8752299
JAMA. 2004 Oct 13;292(14):1696-701
pubmed: 15479934
Cytokine. 2019 Aug;120:115-124
pubmed: 31055218
PLoS Pathog. 2008 Nov;4(11):e1000208
pubmed: 19008951
J Infect Dis. 2015 Aug 1;212(3):397-405
pubmed: 25635121
J Immunol. 2010 Nov 1;185(9):5377-83
pubmed: 20935207
Nat Rev Immunol. 2022 Apr;22(4):236-250
pubmed: 34312520
Rev Med Virol. 2009 May;19(3):165-78
pubmed: 19367611
Nat Immunol. 2020 Apr;21(4):412-421
pubmed: 32066954
Mucosal Immunol. 2011 Nov;4(6):603-11
pubmed: 21975936
N Engl J Med. 1996 Oct 3;335(14):1022-8
pubmed: 8793926
PLoS Pathog. 2015 Feb 27;11(2):e1004626
pubmed: 25723501