Graded lower body negative pressure induces intraventricular negative pressures and incremental diastolic suction: a pressure-volume study in a porcine model.

Animals Dobutamine Hemodynamics Hypovolemia Lower Body Negative Pressure Stroke Volume / physiology Suction Swine Ventricular Function, Left / physiology
diastolic suction invasive hemodynamics lower body negative pressure pressure-volume loops

Journal

Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536

Informations de publication

Date de publication:
01 07 2022
Historique:
pubmed: 13 5 2022
medline: 25 6 2022
entrez: 12 5 2022
Statut: ppublish

Résumé

Lower body negative pressure (LBNP) is a tool to study compensatory mechanisms to central hypovolemia for decades. However, the underlying hemodynamic mechanisms were mostly assessed noninvasively and remain unclear. We hypothesized that incremental LBNP reduces diastolic filling and thereby affects left ventricular (LV) diastolic suction (DS). Here, we investigated the impact of graded LBNP at three different levels of seal as well as during β-adrenergic stimulation by invasive pressure-volume (PV) analysis. Eight Landrace pigs were instrumented closed-chest for PV assessment. LBNP was applied at three consecutive locations:

Identifiants

DOI: 10.1152/japplphysiol.00110.2022 PMID: 35546125
pubmed: 35546125
doi: 10.1152/japplphysiol.00110.2022
doi:

Substances chimiques

Dobutamine 3S12J47372

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

20-26

Subventions

Organisme : Berlin Institute of Health (BIH)
Organisme : K.H. Tscheliessnigg foundation

Auteurs

Leonhard Berboth (L)

Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
ORCID: 0000-0002-4896-2095

Birgit Zirngast (B)

Department of Cardiac Surgery, Medical University of Graz, Graz, Austria.

Martin Manninger (M)

Department of Cardiology, University Clinic of Medicine, Medical University of Graz, Graz, Austria.

Paul Steendijk (P)

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Carsten Tschöpe (C)

Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Daniel Scherr (D)

Department of Cardiology, University Clinic of Medicine, Medical University of Graz, Graz, Austria.

Helmut G Hinghofer-Szalkay (HG)

Institute of Physiology, Centre of Physiological Medicine, Medical University of Graz, Graz, Austria.

Nandu Goswami (N)

Institute of Physiology, Centre of Physiological Medicine, Medical University of Graz, Graz, Austria.
Mohammed Bin Rashid University of Medicine and Health Science, Dubai Healthcare City, Dubai, United Arab Emirates.
ORCID: 0000-0002-6704-0723

Lonnie G Petersen (LG)

Department of Radiology, University of California, San Diego, California.
Mechanical and Aerospace Engineering, University of California, San Diego, California.
ORCID: 0000-0002-5155-9651

Heinrich Mächler (H)

Department of Cardiac Surgery, Medical University of Graz, Graz, Austria.

Alessio Alogna (A)

Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
ORCID: 0000-0001-5988-2720

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Classifications MeSH

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