Energy balance-related factors and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status.
Colorectal cancer
Energy balance
Etiological heterogeneity
Mismatch repair/microsatellite instability
Mutations
Prospective cohort study
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
13
01
2022
accepted:
06
04
2022
pubmed:
14
5
2022
medline:
16
9
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
KRAS mutations (KRAS Information on molecular features was available for 2349 incident CRC cases within the Netherlands Cohort Study (NLCS), with complete covariate data available for 1934 cases and 3911 subcohort members. Multivariable-adjusted Cox-regression was used to estimate associations of energy balance-related factors with risk of CRC based on individual molecular features (KRAS In men, BMI and clothing-size were positively associated with risk of colon, but not rectal cancer, regardless of molecular features subgroups; the strongest associations were observed for PIK3CA In men, associations did not vary according to molecular features. In women, a role of KRAS mutations in the etiological pathway between adiposity and colon cancer is suggested, and of PIK3CA mutations between physical activity and colon cancer.
Identifiants
pubmed: 35546360
doi: 10.1007/s00432-022-04019-9
pii: 10.1007/s00432-022-04019-9
pmc: PMC9470639
doi:
Substances chimiques
KRAS protein, human
0
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
PIK3CA protein, human
EC 2.7.1.137
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2723-2742Subventions
Organisme : KWF Kankerbestrijding
ID : 11044
Informations de copyright
© 2022. The Author(s).
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