Multimodal pain assessment improves discrimination between noxious and non-noxious stimuli in infants.
EEG
infant
machine learning
pain
Journal
Paediatric & neonatal pain
ISSN: 2637-3807
Titre abrégé: Paediatr Neonatal Pain
Pays: United States
ID NLM: 101777799
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
28
03
2019
revised:
25
06
2019
accepted:
07
08
2019
entrez:
13
5
2022
pubmed:
9
9
2019
medline:
9
9
2019
Statut:
epublish
Résumé
Infants in neonatal intensive care units frequently experience clinically necessary painful procedures, which elicit a range of behavioral, physiological, and neurophysiological responses. However, the measurement of pain in this population is a challenge and no gold standard exists. The aim of this study was to investigate how noxious-evoked changes in facial expression, reflex withdrawal, brain activity, heart rate, and oxygen saturation are related and to examine their accuracy in discriminating between noxious and non-noxious stimuli. In 109 infants who received a clinically required heel lance and a control non-noxious stimulus, we investigated whether combining responses across each modality, or including multiple measures from within each modality improves our ability to discriminate the noxious and non-noxious stimuli. A random forest algorithm was used to build data-driven models to discriminate between the noxious and non-noxious stimuli in a training set which were then validated in a test set of independent infants. Measures within each modality were highly correlated, while different modalities showed less association. The model combining information across all modalities had good discriminative ability (accuracy of 0.81 in identifying noxious and non-noxious stimuli), which was higher than the discriminative power of the models built from individual modalities. This demonstrates the importance of including multiple modalities in the assessment of infant pain.
Identifiants
pubmed: 35546868
doi: 10.1002/pne2.12007
pii: PNE212007
pmc: PMC8974881
doi:
Types de publication
Journal Article
Langues
eng
Pagination
21-30Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Paediatric and Neonatal Pain published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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