Temperament Dimensions and Awakening Cortisol Levels in Attention-Deficit/Hyperactivity Disorder.

To investigate whether temperament dimensions, Effortful Control (EC), Surgency-Extraversion (SE), and Negative Affectivity (NA), are associated with attention-deficit/hyperactivity disorder (ADHD) and how they relate to awakening cortisol levels, as a proxy measure of peripheral arousal. Parent-rated temperament and saliva samples were collected from 55 children with ADHD and 65 age-matched controls. Compared to controls, youths with ADHD showed lower EC, higher NA, and lower awakening cortisol levels but did not differ in SE. Similar findings emerged in dimensional analyses linking temperament traits to inattention and hyperactivity-impulsivity symptoms. The results remained unchanged when controlling for the presence of co-occurring opposition-defiance and anxiety traits, as well as medication status. Temperament dimensions were not associated with cortisol levels. Poor temperamental emotional and cognitive self-regulation showed significant associations with ADHD but did not appear to be linked to the under-arousal typically seen in ADHD.

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Copyright © 2022 Carta, Vainieri, Rommel, Zuddas, Kuntsi, Sotgiu and Adamo.

Déclaration de conflit d'intérêts

JK has given talks at educational events sponsored by Medice; all funds are received by King's College London and used for studies of ADHD. AZ served in an advisory or consultancy role for Angelini, EduPharma, Servier. He received conference support or speaker's fee by Angelini and Janssen. He has been involved in clinical trials conducted by Angelini, Janssen, Lundbeck, Otsuka, Roche, Sevier, and Shire. He received royalties from Giunti OS, Oxford University Press. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer PK declared a shared affiliation with the A-SR at the time of review.