Longitudinal and Comparative Analysis of Gut Microbiota of Tunisian Newborns According to Delivery Mode.
ESKAPE bacteria
Tunisia
elective cesarean deliveries
microbiome
newborns
shotgun metagenome sequencing
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
09
2021
accepted:
15
03
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
Microbiota colonization is a dynamic process that impacts the health status during an individual's lifetime. The composition of the gut microbiota of newborns is conditioned by multiple factors, including the delivery mode (DM). Nonetheless, the DM's influence remains uncertain and is still the subject of debate. In this context, the medical indication and the emergency of a cesarean delivery might have led to confounding conclusions regarding the composition and diversity of the neonatal microbiome. Herein, we used high-resolution shotgun sequencing to decipher the composition and dynamics of the gut microbiota composition of Tunisian newborns. Stool samples were collected from 5 elective cesarean section (ECS) and 5 vaginally delivered (VD) newborns at the following time points: Day 0, Day 15, and Day 30. The ECS and VD newborns showed the same level of bacterial richness and diversity. In addition, our data pointed to a shift in microbiota community composition during the first 2 weeks, regardless of the DM. Both ECS and VD showed a profile dominated by Proteobacteria, Actinobacteria, and Firmicutes. However, ECS showed an underrepresentation of
Identifiants
pubmed: 35547149
doi: 10.3389/fmicb.2022.780568
pmc: PMC9083410
doi:
Types de publication
Journal Article
Langues
eng
Pagination
780568Informations de copyright
Copyright © 2022 Hanachi, Maghrebi, Bichiou, Trabelsi, Bouyahia, Zhioua, Belghith, Harigua-Souiai, Baouendi, Guizani-Tabbane, Benkahla and Souiai.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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