Development of a microfluidic platform to maintain viability of micro-dissected tumor slices in culture.
Journal
Biomicrofluidics
ISSN: 1932-1058
Titre abrégé: Biomicrofluidics
Pays: United States
ID NLM: 101293825
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
07
02
2022
accepted:
06
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
One of the issues limiting the development of personalized medicine is the absence of realistic models that reflect the nature and complexity of tumor tissues. We described a new tissue culture approach that combines a microfluidic chip with the microdissected breast cancer tumor. "Tumor-on-a-chip" devices are suitable for precision medicine since the viability of tissue samples is maintained during the culture period by continuously feeding fresh media and eliminating metabolic wastes from the tissue. However, the mass transport of oxygen, which arguably is the most critical nutrient, is rarely assessed. According to our results, transportation of oxygen provides satisfactory
Identifiants
pubmed: 35547184
doi: 10.1063/5.0087532
pii: 5.0087532
pmc: PMC9076128
doi:
Types de publication
Journal Article
Langues
eng
Pagination
034103Informations de copyright
© 2022 Author(s).
Références
Sensors (Basel). 2015 Dec 10;15(12):31142-70
pubmed: 26690442
Sci Rep. 2019 Jan 9;9(1):1
pubmed: 30626917
J Nanosci Nanotechnol. 2015 Jul;15(7):4806-14
pubmed: 26373041
Breast Cancer Res. 2017 Apr 21;19(1):50
pubmed: 28427436
Biotechnol Bioeng. 2010 Jan 1;105(1):184-94
pubmed: 19718695
Otolaryngol Head Neck Surg. 2014 Jan;150(1):73-80
pubmed: 24098006
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8352-6
pubmed: 20404174
Bioeng Transl Med. 2016 Jul 05;1(1):63-81
pubmed: 29313007
Nat Protoc. 2010 Sep;5(9):1540-51
pubmed: 20725069
Biomicrofluidics. 2021 Aug 27;15(4):044103
pubmed: 34504636
NPJ Precis Oncol. 2020 Jan 6;4:1
pubmed: 31934644
Lab Chip. 2016 Jan 21;16(2):312-25
pubmed: 26659477
Science. 2017 Nov 17;358(6365):941-946
pubmed: 29025995
Methods Mol Biol. 2011;740:127-40
pubmed: 21468974
Transl Oncol. 2020 Jan;13(1):1-10
pubmed: 31726354
Microsyst Nanoeng. 2020 Feb 10;6:1
pubmed: 34567616