Complement Mediated Endothelial Damage in Thrombotic Microangiopathies.
C5b-9 deposition
complement blockade
complement system activation
endothelia cells
membrane attack complex
thrombotic microangiopathies
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
11
2021
accepted:
14
03
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
Thrombotic microangiopathies (TMA) constitute a group of different disorders that have a common underlying mechanism: the endothelial damage. These disorders may exhibit different mechanisms of endothelial injury depending on the pathological trigger. However, over the last decades, the potential role of the complement system (CS) has gained prominence in their pathogenesis. This is partly due to the great efficacy of complement-inhibitors in atypical hemolytic syndrome (aHUS), a TMA form where the primary defect is an alternative complement pathway dysregulation over endothelial cells (genetic and/or adquired). Complement involvement has also been demonstrated in other forms of TMA, such as thrombotic thrombocytopenic purpura (TTP) and in Shiga toxin-producing
Identifiants
pubmed: 35547236
doi: 10.3389/fmed.2022.811504
pmc: PMC9082680
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
811504Informations de copyright
Copyright © 2022 Blasco, Guillén-Olmos, Diaz-Ricart and Palomo.
Déclaration de conflit d'intérêts
MB reports advisory boards and symposium speaker honoraria from Alexion Pharmaceuticals. MD-R has received research funding and speaker fees from Jazz Pharmaceuticals. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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