Managing Musculoskeletal and Kidney Aging: A Call for Holistic Insights.
kidney disease
older individuals
osteoporosis
sarcopenia
senolytics
Journal
Clinical interventions in aging
ISSN: 1178-1998
Titre abrégé: Clin Interv Aging
Pays: New Zealand
ID NLM: 101273480
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
01
2022
accepted:
20
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Aging represents a major concern, with a two-fold increase in individuals >65 years old by 2040. Older patients experience multiple declines in condition, with overlapping concerns. Fractures, frailty and falls remain underestimated events in routine practice. They are shared by numerous conditions and diseases, such as osteoporosis, sarcopenia and undernutrition, which mostly feature low evolution and are silent. In this review, we focused on musculoskeletal decline in older individuals who also have chronic kidney disease (CKD), which promotes fractures and falls. We aimed to highlight the need for a global approach for musculoskeletal and kidney aging. Although strategies limiting falls remain controversial, the need for an early diagnosis can limit these declines and allow for specific treatment of bone fragility in addition to non-pharmacological approaches. The emergence of senolytic agents offers new hope for preventing musculoskeletal disorders. This scoping review describes these overlapping silent diseases, provides evidence for their global understanding and management, and sheds light on new therapeutic directions.
Identifiants
pubmed: 35548383
doi: 10.2147/CIA.S357501
pii: 357501
pmc: PMC9081621
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
717-732Informations de copyright
© 2022 Cailleaux and Cohen-Solal.
Déclaration de conflit d'intérêts
Pierre-Emmanuel Cailleaux declares that he has no competing interest. Martine Cohen-Solal declares that she has no competing interest.
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