Syndecan-1 Is Overexpressed in Human Thoracic Aneurysm but Is Dispensable for the Disease Progression in a Mouse Model.
Syndecan-1
aneurysm
extracellular matrix
proteoglycan
smooth muscle cell (SMC)
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
12
2021
accepted:
07
03
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
Glycosaminoglycans (GAGs) pooling has long been considered as one of the histopathological characteristics defining thoracic aortic aneurysm (TAA) together with smooth muscle cells (SMCs) apoptosis and elastin fibers degradation. However, little information is known about GAGs composition or their potential implication in TAA pathology. Syndecan-1 (SDC-1) is a heparan sulfate proteoglycan that is implicated in extracellular matrix (ECM) interaction and assembly, regulation of SMCs phenotype, and various aspects of inflammation in the vascular wall. Therefore, the aim of this study was to determine whether SDC-1 expression was regulated in human TAA and to analyze its role in a mouse model of this disease. In the current work, the regulation of SDC-1 was examined in human biopsies by RT-qPCR, ELISA, and immunohistochemistry. In addition, the role of SDC-1 was evaluated in descending TAA
Identifiants
pubmed: 35548440
doi: 10.3389/fcvm.2022.839743
pmc: PMC9082175
doi:
Types de publication
Journal Article
Langues
eng
Pagination
839743Informations de copyright
Copyright © 2022 Zalghout, Vo, Arocas, Jadoui, Hamade, Badran, Oudar, Charnaux, Longrois, Boulaftali, Bouton and Richard.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):1899-1901
pubmed: 31553667
Am J Pathol. 1994 Jun;144(6):1348-56
pubmed: 8203472
J Vasc Surg. 2012 Aug;56(2):565-71
pubmed: 22840907
Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1135-41
pubmed: 11923257
Circulation. 2006 Dec 12;114(24):2611-8
pubmed: 17145990
Sci Rep. 2018 Jun 4;8(1):8550
pubmed: 29867203
Circulation. 2012 Dec 18;126(25):3070-80
pubmed: 23136157
J Vasc Res. 2013;50(1):1-10
pubmed: 23018968
Exp Mol Med. 2019 Dec 19;51(12):1-15
pubmed: 31857579
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):386-96
pubmed: 22173227
Herz. 2019 Apr;44(2):138-146
pubmed: 30747234
J Immunol. 2009 Apr 15;182(8):4985-93
pubmed: 19342678
Cardiovasc Pathol. 2016 May-Jun;25(3):247-257
pubmed: 27031798
Cytokine. 2018 Nov;111:140-145
pubmed: 30142535
An Bras Dermatol. 2018 Jun;93(3):415-418
pubmed: 29924246
Hypertension. 2010 May;55(5):1267-74
pubmed: 20212272
J Thorac Cardiovasc Surg. 2008 Nov;136(5):1123-30
pubmed: 19026791
Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1356-62
pubmed: 19592464
Mol Cell Proteomics. 2011 Aug;10(8):M111.008128
pubmed: 21593211
FASEB J. 2005 Sep;19(11):1528-30
pubmed: 16014397
Mediators Inflamm. 2017;2017:1274034
pubmed: 29203969
PLoS One. 2015 Apr 13;10(4):e0124013
pubmed: 25875748
Sci Rep. 2016 Jun 22;6:28149
pubmed: 27329825
Biomech Model Mechanobiol. 2014 Jan;13(1):13-25
pubmed: 23494585
Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1197-205
pubmed: 18156194
Circulation. 2007 Jan 30;115(4):475-82
pubmed: 17242279
JCI Insight. 2018 Mar 8;3(5):
pubmed: 29515038
Blood. 2009 Oct 1;114(14):3033-43
pubmed: 19638625
Biomedicines. 2021 Jun 20;9(6):
pubmed: 34203009
J Cell Sci. 2002 Dec 1;115(Pt 23):4517-31
pubmed: 12414997
Surg Clin North Am. 2009 Aug;89(4):845-67, ix
pubmed: 19782841
J Cell Mol Med. 2007 Mar-Apr;11(2):176-205
pubmed: 17488472
Am J Cardiol. 1977 Jan;39(1):21-6
pubmed: 831424
PLoS One. 2014 Feb 25;9(2):e89824
pubmed: 24587062
J Immunol. 2006 Nov 15;177(10):7233-41
pubmed: 17082641
Clin Chim Acta. 1994 Apr;226(1):29-46
pubmed: 8070133
Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):332-40
pubmed: 25550207
Arterioscler Thromb Vasc Biol. 1998 Apr;18(4):604-14
pubmed: 9580254
J Vasc Surg. 2007 Nov;46(5):1014-25
pubmed: 17905554
J Mol Cell Cardiol. 2014 Oct;75:174-80
pubmed: 25093698
Int J Exp Pathol. 2000 Jun;81(3):173-82
pubmed: 10971738
Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2370-6
pubmed: 17717298
Int J Mol Sci. 2020 Oct 16;21(20):
pubmed: 33081376
Cell Tissue Res. 2010 Jan;339(1):31-46
pubmed: 19597846
J Cell Physiol. 2007 Apr;211(1):167-73
pubmed: 17149710
Int J Biochem Cell Biol. 2007;39(3):505-28
pubmed: 17097330