The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival.

Antigens, Viral Epstein-Barr Virus Infections / complications Glioma / complications Herpesvirus 4, Human / genetics Humans Immunogenetics Multiple Sclerosis / genetics
Epstein-Barr virus Merkel cell polyomavirus glioma human leukocyte antigen polygenic risk score

Journal

American journal of human genetics
ISSN: 1537-6605
Titre abrégé: Am J Hum Genet
Pays: United States
ID NLM: 0370475

Informations de publication

Date de publication:
02 06 2022
Historique:
received: 29 11 2021
accepted: 18 04 2022
pubmed: 14 5 2022
medline: 9 6 2022
entrez: 13 5 2022
Statut: ppublish

Résumé

Glioma is a highly fatal cancer with prognostically significant molecular subtypes and few known risk factors. Multiple studies have implicated infections in glioma susceptibility, but evidence remains inconsistent. Genetic variants in the human leukocyte antigen (HLA) region modulate host response to infection and have been linked to glioma risk. In this study, we leveraged genetic predictors of antibody response to 12 viral antigens to investigate the relationship with glioma risk and survival. Genetic reactivity scores (GRSs) for each antigen were derived from genome-wide-significant (p < 5 × 10

Identifiants

DOI: 10.1016/j.ajhg.2022.04.011 PMID: 35550063 PMC: PMC9247888
pubmed: 35550063
pii: S0002-9297(22)00159-8
doi: 10.1016/j.ajhg.2022.04.011
pmc: PMC9247888
pii:
doi:

Substances chimiques

Antigens, Viral 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1105-1116

Subventions

Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : T32 CA151022
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA230712
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097257
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA246076
Pays : United States

Informations de copyright

Copyright © 2022. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Geno Guerra (G)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. Electronic address: geno.guerra@ucsf.edu.

Linda Kachuri (L)

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

George Wendt (G)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.

Helen M Hansen (HM)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.

Steven J Mack (SJ)

Department of Pediatrics, University of California, San Francisco, Oakland, CA, USA.

Annette M Molinaro (AM)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

Terri Rice (T)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.

Paige Bracci (P)

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

John K Wiencke (JK)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; Institute of Human Genetics, University of California, San Francisco, San Francisco, CA, USA.

Nori Kasahara (N)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, USA.

Jeanette E Eckel-Passow (JE)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Robert B Jenkins (RB)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Margaret Wrensch (M)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Institute of Human Genetics, University of California, San Francisco, San Francisco, CA, USA.

Stephen S Francis (SS)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, USA. Electronic address: stephen.francis@ucsf.edu.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › The immunogenetics of viral antigen response...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus oncogènes › Infections à virus Epstein-Barr › The immunogenetics of viral antigen response...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › The immunogenetics of viral antigen response...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Gammaherpesvirinae › Lymphocryptovirus › Herpèsvirus humain de type 4 › The immunogenetics of viral antigen response...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The immunogenetics of viral antigen response...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Immunogénétique › The immunogenetics of viral antigen response...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › The immunogenetics of viral antigen response...