Translational approaches to influence sleep and arousal.
CBT-I
Deep brain stimulation
Non-invasive stimulation
Pitolisant
Suvorexant
Zolpidem
Journal
Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
12
01
2022
revised:
27
04
2022
accepted:
03
05
2022
pubmed:
14
5
2022
medline:
7
6
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Sleep disorders are widespread in society and are prevalent in military personnel and in Veterans. Disturbances of sleep and arousal mechanisms are common in neuropsychiatric disorders such as schizophrenia, post-traumatic stress disorder, anxiety and affective disorders, traumatic brain injury, dementia, and substance use disorders. Sleep disturbances exacerbate suicidal ideation, a major concern for Veterans and in the general population. These disturbances impair quality of life, affect interpersonal relationships, reduce work productivity, exacerbate clinical features of other disorders, and impair recovery. Thus, approaches to improve sleep and modulate arousal are needed. Basic science research on the brain circuitry controlling sleep and arousal led to the recent approval of new drugs targeting the orexin/hypocretin and histamine systems, complementing existing drugs which affect GABA
Identifiants
pubmed: 35550156
pii: S0361-9230(22)00116-2
doi: 10.1016/j.brainresbull.2022.05.002
pmc: PMC9554922
mid: NIHMS1839357
pii:
doi:
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
140-161Subventions
Organisme : NIA NIH HHS
ID : K01 AG068366
Pays : United States
Organisme : BLRD VA
ID : I01 BX004673
Pays : United States
Organisme : RRD VA
ID : I01 RX001144
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS119227
Pays : United States
Organisme : BLRD VA
ID : I01 BX001404
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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