Circulating 1,3-Beta-D-Glucan is Associated with Lung Function, Respiratory Symptoms, and Mediators of Matrix Degradation in Chronic Obstructive Pulmonary Disease.
chronic obstructive pulmonary disease
microbial translocation
Journal
Chronic obstructive pulmonary diseases (Miami, Fla.)
ISSN: 2372-952X
Titre abrégé: Chronic Obstr Pulm Dis
Pays: United States
ID NLM: 101635411
Informations de publication
Date de publication:
29 Jul 2022
29 Jul 2022
Historique:
pubmed:
14
5
2022
medline:
14
5
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Factors beyond cigarette smoke likely contribute to chronic obstructive pulmonary disease (COPD) pathogenesis. Prior studies demonstrate fungal colonization of the respiratory tract and increased epithelial barrier permeability in COPD. We sought to determine whether 1,3-beta-d-glucan (BDG), a polysaccharide component of the fungal cell wall, is detectable in the plasma of individuals with COPD and associates with clinical outcomes and matrix degradation proteins. BDG was measured in the plasma of current and former smokers with COPD. High BDG was defined as a value greater than the 95 COPD participants with high BDG plasma levels (19.8%) had lower forced expiratory volume in 1 second to forced vital capacity ratios (median 31.9 versus 39.3, Elevated plasma BDG levels correlate with worse lung function, greater respiratory morbidity, and circulating markers of matrix degradation in COPD. These findings suggest that targeting dysbiosis or enhancing epithelial barrier integrity may have disease-modifying effects in COPD.
Identifiants
pubmed: 35550241
doi: 10.15326/jcopdf.2022.0290
pmc: PMC9448008
doi:
Types de publication
Journal Article
Langues
eng
Pagination
325-335Subventions
Organisme : NHLBI NIH HHS
ID : P50 HL084948
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128289
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153400
Pays : United States
Informations de copyright
JCOPDF © 2022.
Références
Eur Respir J. 2005 May;25(5):885-90
pubmed: 15863647
Respir Res. 2019 Jun 6;20(1):113
pubmed: 31170986
Front Immunol. 2018 Apr 16;9:673
pubmed: 29755450
Blood Purif. 2019;47(1-3):28-36
pubmed: 30219816
COPD. 2005 Mar;2(1):75-9
pubmed: 17136966
Clin Infect Dis. 2020 May 23;70(11):2413-2422
pubmed: 31260509
Nat Commun. 2020 Nov 18;11(1):5886
pubmed: 33208745
PLoS One. 2021 Apr 9;16(4):e0249944
pubmed: 33836012
Infect Immun. 2005 Dec;73(12):7967-76
pubmed: 16299289
BMC Nephrol. 2020 Apr 6;21(1):118
pubmed: 32252666
Matrix Biol. 2018 Nov;73:34-51
pubmed: 29406250
Nat Rev Cardiol. 2019 Mar;16(3):137-154
pubmed: 30410105
Immunobiology. 2021 Mar;226(2):152071
pubmed: 33588306
ERJ Open Res. 2021 Sep 13;7(3):
pubmed: 34527724
JCI Insight. 2018 Feb 8;3(3):
pubmed: 29415878
Circulation. 2019 Jan 29;139(5):663-678
pubmed: 30586706
Tohoku J Exp Med. 2009 Feb;217(2):117-21
pubmed: 19212104
Am J Respir Crit Care Med. 2015 Apr 15;191(8):932-42
pubmed: 25603113
Respir Med. 2019 Oct;157:1-6
pubmed: 31450162
Chronic Obstr Pulm Dis. 2018 Oct 12;5(4):324-333
pubmed: 30723788
Clin Infect Dis. 2021 Oct 5;73(7):e1415-e1422
pubmed: 32914187
Microbiome. 2019 Mar 11;7(1):37
pubmed: 30857553
Diagn Microbiol Infect Dis. 2017 Aug;88(4):316-321
pubmed: 28622948
Int J Mol Sci. 2017 Sep 05;18(9):
pubmed: 28872611
Inflamm Res. 2016 Mar;65(3):235-44
pubmed: 26644324
Arch Pathol Lab Med. 2016 Feb;140(2):181-5
pubmed: 26910223
PLoS One. 2011 Apr 07;6(4):e14793
pubmed: 21490961
Chest. 2014 Feb;145(2):245-252
pubmed: 23928850
Int J Chron Obstruct Pulmon Dis. 2014 Feb 21;9:229-38
pubmed: 24591822
J Clin Invest. 2017 Jun 30;127(7):2829-2841
pubmed: 28530644
Pharmacol Res. 2019 Mar;141:366-377
pubmed: 30639376
J Diabetes Metab Disord. 2014 Jun 04;13:66
pubmed: 24991533
J Immunol. 2017 Jan 1;198(1):61-70
pubmed: 27852745
Lancet Respir Med. 2017 Sep;5(9):691-706
pubmed: 28822787
J Immunol. 2004 Jul 15;173(2):797-806
pubmed: 15240666
World J Gastroenterol. 2021 Mar 7;27(9):866-885
pubmed: 33727775
J Am Coll Cardiol. 2019 Apr 30;73(16):2089-2105
pubmed: 31023434
Clin Infect Dis. 2020 Jan 2;70(2):232-241
pubmed: 30877304
MMWR Morb Mortal Wkly Rep. 2021 Apr 09;70(14):519-522
pubmed: 33830988
BMC Pulm Med. 2019 Jun 24;19(1):112
pubmed: 31234826
Int J Chron Obstruct Pulmon Dis. 2016 May 27;11:1129-37
pubmed: 27313452
Am J Respir Crit Care Med. 2008 Oct 1;178(7):738-44
pubmed: 18565949
Ann Med. 2013 May;45(3):291-300
pubmed: 23110517
Mycoses. 2018 Oct;61(10):718-722
pubmed: 29855088
Am J Respir Crit Care Med. 2004 Aug 15;170(4):408-13
pubmed: 15117741
Respir Res. 2014 Jun 30;15:74
pubmed: 24980707
J Immunol. 2012 Oct 1;189(7):3653-60
pubmed: 22933634
J Res Med Sci. 2016 Mar 15;21:12
pubmed: 27904558
Respiration. 2018;95(5):334-342
pubmed: 29393240
Kaohsiung J Med Sci. 2020 Feb;36(2):107-113
pubmed: 31782610
J Acquir Immune Defic Syndr. 2012 Dec 1;61(4):462-8
pubmed: 22972021
Cell Rep. 2020 Mar 31;30(13):4386-4398.e5
pubmed: 32234475
JCI Insight. 2021 Jul 22;6(14):
pubmed: 34128840
Eur J Immunol. 2008 Feb;38(2):500-6
pubmed: 18200499
Cell Microbiol. 2005 Apr;7(4):471-9
pubmed: 15760447
PLoS One. 2015 Jul 06;10(7):e0130736
pubmed: 26147303
PLoS One. 2009 Nov 12;4(11):e7818
pubmed: 19915667
J Endotoxin Res. 2007;13(3):140-9
pubmed: 17621556