CD4 T cell responses in persistent Borrelia burgdorferi infection.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
04
03
2022
accepted:
07
04
2022
pubmed:
14
5
2022
medline:
3
8
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Infection of mice with Borrelia burgdorferi (Bb), a tick-transmitted spirochete and the pathogen that causes Lyme disease in humans, triggers CD4 T cell activation in secondary lymphoid tissues, from which they disseminate into various infected tissues. Despite their activation and the appearance of CD4 T cell-dependent antibody responses, Bb establishes persistent infection in natural Bb reservoir hosts in the absence of overt disease, raising the question of the effectiveness of the anti-Bb T cell responses. Reviewing the existing literature, we propose that CD4 T cells might constitute a host cell target of Bb-mediated immune evasion, rendering these cells ineffective in orchestrating effective inflammatory responses and in supporting highly functional Bb-specific antibody induction. Supporting the induction of more effective CD4 T cell responses may help overcome Bb persistence.
Identifiants
pubmed: 35550259
pii: S0952-7915(22)00034-6
doi: 10.1016/j.coi.2022.102187
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102187Subventions
Organisme : NIAID NIH HHS
ID : T32 AI060555
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI157007
Pays : United States
Informations de copyright
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