Loneliness inside of the brain: evidence from a large dataset of resting-state fMRI in young adult.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 05 2022
12 05 2022
Historique:
received:
25
01
2022
accepted:
25
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Although loneliness itself is a natural emotion, prolonged loneliness is detrimental to human health. Despite its detrimental effect, few loneliness-related neuroimaging studies have been published and some have limitations on the sample size number. This study aims to find the difference in resting-state functional connectivity associated with loneliness within a big sample size via the seed-based approach. Functional connectivity analysis was performed on a large cohort of young adults (N = 1336) using the seed-based functional connectivity approach to address the concern from previous studies. The analysis yielded statistically significant positive correlations between loneliness and functional connectivities between the inferior frontal gyrus and supplementary motor area, precentral gyrus, and superior parietal lobule. Additionally, the analysis replicated a finding from a previous study, which is increased functional connectivities between the inferior frontal gyrus and supplementary motor area. In conclusion, greater loneliness is reflected by stronger functional connectivity of the visual attention brain area.
Identifiants
pubmed: 35550564
doi: 10.1038/s41598-022-11724-5
pii: 10.1038/s41598-022-11724-5
pmc: PMC9098468
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7856Informations de copyright
© 2022. The Author(s).
Références
J Adolesc Health. 2015 Feb;56(2):127-9
pubmed: 25620297
Front Hum Neurosci. 2013 May 29;7:232
pubmed: 23755001
Soc Cogn Affect Neurosci. 2014 Nov;9(11):1762-9
pubmed: 24194581
Ann Behav Med. 2010 Oct;40(2):218-27
pubmed: 20652462
Gastroenterol Hepatol Bed Bench. 2013 Winter;6(1):14-7
pubmed: 24834239
Sci Rep. 2019 Sep 19;9(1):13569
pubmed: 31537846
Curr Biol. 2012 Dec 4;22(23):2274-7
pubmed: 23122848
J Psychol. 1993 Jan;127(1):65-71
pubmed: 8510053
Neuroreport. 2014 Aug 6;25(11):843-847
pubmed: 29504966
Neuroimage. 2017 May 15;152:258-269
pubmed: 28257930
J Cogn Neurosci. 2009 Jan;21(1):83-92
pubmed: 18476760
PLoS One. 2018 Mar 22;13(3):e0194021
pubmed: 29566046
Exp Brain Res. 2015 Jan;233(1):157-64
pubmed: 25234401
Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34
pubmed: 20471808
Acta Biomed. 2018 Jun 07;89(2):302-314
pubmed: 29957768
Soc Psychiatry Psychiatr Epidemiol. 2016 Oct;51(10):1373-1384
pubmed: 27571769
Curr Biol. 2012 Oct 23;22(20):1975-9
pubmed: 23041193
J Neurosci. 2015 Jun 10;35(23):8737-44
pubmed: 26063908
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Neuroinformatics. 2016 Jul;14(3):339-51
pubmed: 27075850
Soc Cogn Affect Neurosci. 2019 May 17;14(4):423-433
pubmed: 30924854
Front Hum Neurosci. 2016 Jun 17;10:298
pubmed: 27378891
Neuroimage. 2010 Apr 15;50(3):1313-9
pubmed: 20056157
Neuroimage. 2008 Mar 1;40(1):298-307
pubmed: 18178107
Hum Brain Mapp. 2016 Nov;37(11):3957-3978
pubmed: 27329401
Neuropsychologia. 2011 Oct;49(12):3466-73
pubmed: 21906608
Neuroimage. 2008 Jul 1;41(3):1168-76
pubmed: 18434203
J Appl Philos. 2001;18(3):245-56
pubmed: 11981991
Soc Cogn Affect Neurosci. 2016 Jul;11(7):1096-101
pubmed: 26084531
Neuroimage. 2017 Jul 1;154:169-173
pubmed: 27888059
Perspect Psychol Sci. 2015 Mar;10(2):250-64
pubmed: 25910393
PLoS One. 2017 May 18;12(5):e0177443
pubmed: 28545125
Neuroimage. 2014 Jan 1;84:320-41
pubmed: 23994314
J Pers Assess. 1996 Feb;66(1):20-40
pubmed: 8576833
Neurol Med Chir (Tokyo). 2014;54(7):511-20
pubmed: 24305024
Neuroimage. 2015 Oct 1;119:197-209
pubmed: 26123381
Neuroimage. 2013 Aug 15;77:222-36
pubmed: 23578577
Neuroimage. 2020 Nov 1;221:117164
pubmed: 32679253
Nat Commun. 2020 Dec 15;11(1):6393
pubmed: 33319780
Scand J Psychol. 2018 Aug;59(4):351-359
pubmed: 29516516
Neuroscientist. 2014 Apr;20(2):150-9
pubmed: 23835449
Soc Cogn Affect Neurosci. 2013 Feb;8(2):151-7
pubmed: 22089142
Eur Respir J. 2008 Nov;32(5):1141-3
pubmed: 18978131
Biol Psychol. 2017 Dec;130:41-49
pubmed: 28988974
Annu Rev Neurosci. 1999;22:319-49
pubmed: 10202542
Cogn Emot. 2017 Feb;31(2):377-383
pubmed: 26461799
J Neurosci. 2009 Nov 25;29(47):14980-6
pubmed: 19940193
Neuroimage. 2017 Jan 15;145(Pt A):58-73
pubmed: 27664824
Cereb Cortex. 2012 Dec;22(12):2921-9
pubmed: 22235031
Nat Neurosci. 2020 Dec;23(12):1597-1605
pubmed: 33230328
J Neurosci. 2009 Aug 12;29(32):10153-9
pubmed: 19675249
Nat Rev Neurosci. 2006 Dec;7(12):942-51
pubmed: 17115076
Neuroimage. 2011 Jan 15;54(2):992-1000
pubmed: 20849959
Front Syst Neurosci. 2010 Apr 06;4:8
pubmed: 20407579
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Nature. 1994 Sep 29;371(6496):413-6
pubmed: 8090219
Clin Psychol Rev. 2017 Dec;58:97-114
pubmed: 29102150
Neuroimage. 2013 Aug 1;76:183-201
pubmed: 23499792
Br J Dev Psychol. 2020 Mar;38(1):144-148
pubmed: 31553096
Psychol Sci. 2005 Oct;16(10):798-804
pubmed: 16181443
Sci Rep. 2015 Nov 20;5:17001
pubmed: 26585372
Magn Reson Med. 1996 Mar;35(3):346-55
pubmed: 8699946