The early-life exposome modulates the effect of polymorphic inversions on DNA methylation.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
12 05 2022
12 05 2022
Historique:
received:
18
10
2021
accepted:
19
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23.1, 16p11.2, and 17q21.31 in 1,009 blood samples from children from the Human Early Life Exposome (HELIX) project and in 39 prenatal heart tissue samples. We found inversion-state specific methylation patterns within and nearby flanking each inversion region in both datasets. Additionally, numerous inversion-exposure interactions on methylation levels were identified from early-life exposome data comprising 64 exposures. For instance, children homozygous at inv-8p23.1 and higher meat intake were more susceptible to TDH hypermethylation (P = 3.8 × 10
Identifiants
pubmed: 35550596
doi: 10.1038/s42003-022-03380-2
pii: 10.1038/s42003-022-03380-2
pmc: PMC9098634
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
455Subventions
Organisme : Wellcome Trust
ID : WT101597MA
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N024397/1
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
Références
Annu Rev Psychol. 2014;65:41-70
pubmed: 24405358
Obes Rev. 2014 Sep;15(9):740-8
pubmed: 24815945
PLoS One. 2012;7(7):e41361
pubmed: 22848472
Hum Mol Genet. 2005 Aug 15;14(16):2399-404
pubmed: 16000317
Am J Hum Genet. 1998 Jul;63(1):218-24
pubmed: 9634501
BMC Genomics. 2012 Apr 24;13:143
pubmed: 22530940
Oncogene. 2002 Aug 12;21(35):5361-79
pubmed: 12154399
Nat Genet. 1993 Nov;5(3):236-41
pubmed: 8275087
Pharmacogenet Genomics. 2008 Aug;18(8):733-7
pubmed: 18622266
Environ Health Perspect. 2014 Jun;122(6):535-44
pubmed: 24610234
Int J Hyg Environ Health. 2015 May;218(3):358-65
pubmed: 25757723
Arch Neurol. 2008 Nov;65(11):1473-8
pubmed: 19001166
Am J Hum Genet. 2020 Jun 4;106(6):846-858
pubmed: 32470372
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Cardiovasc Toxicol. 2005 Fall;5(4):345-54
pubmed: 16382172
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
BMC Genomics. 2017 May 26;18(1):413
pubmed: 28549425
Genome Res. 2020 May;30(5):724-735
pubmed: 32424072
Cell. 2019 Mar 21;177(1):38-44
pubmed: 30901546
Semin Cell Dev Biol. 2018 May;77:133-143
pubmed: 29051054
Stat Med. 2011 Feb 20;30(4):377-99
pubmed: 21225900
Am J Hum Genet. 2017 Mar 2;100(3):406-413
pubmed: 28190455
Hum Genomics. 2019 Nov 21;13(1):57
pubmed: 31753042
Evid Based Ment Health. 2019 Nov;22(4):153-160
pubmed: 31563865
Genome Res. 2014 Jul;24(7):1064-74
pubmed: 24709820
PLoS Genet. 2015 Oct 01;11(10):e1005495
pubmed: 26427027
Front Genet. 2019 May 29;10:508
pubmed: 31191618
NPJ Genom Med. 2020 Sep 24;5:41
pubmed: 33062306
BMC Genomics. 2012 Sep 06;13:458
pubmed: 22950410
Epigenetics. 2015;10(2):167-77
pubmed: 25587870
Nucleic Acids Res. 2015 Apr 30;43(8):e53
pubmed: 25672393
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nucleic Acids Res. 2014 Jan;42(Database issue):D1027-32
pubmed: 24253300
BMC Genomics. 2020 Jan 30;21(1):95
pubmed: 32000688
Front Aging Neurosci. 2018 Jan 23;9:446
pubmed: 29472855
Nat Genet. 2012 Jul 01;44(8):872-80
pubmed: 22751100
Environ Int. 2018 Dec;121(Pt 1):751-763
pubmed: 30326459
ERJ Open Res. 2016 Jul 29;2(3):
pubmed: 27730206
Nucleic Acids Res. 2013 Apr;41(7):e90
pubmed: 23476028
J Exp Biol. 2015 Jan 1;218(Pt 1):71-9
pubmed: 25568453
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50
pubmed: 16103423
Heredity (Edinb). 2010 Jul;105(1):105-12
pubmed: 20179736
Arch Neurol. 2011 Mar;68(3):359-64
pubmed: 21403021
PLoS Genet. 2019 Jul 3;15(7):e1008203
pubmed: 31269027
Am J Hum Genet. 2014 Mar 6;94(3):361-72
pubmed: 24560518
Nature. 2008 Mar 6;452(7183):45-50
pubmed: 18322525
Arch Med Sci. 2013 Dec 30;9(6):976-83
pubmed: 24482639
Genome Biol. 2015 Feb 15;16:37
pubmed: 25853392
J Epidemiol Community Health. 2012 Jan;66(1):8-13
pubmed: 22045849
Am J Med Genet B Neuropsychiatr Genet. 2014 Oct;165B(7):541-54
pubmed: 25139739
PLoS One. 2014 Dec 29;9(12):e115614
pubmed: 25545785
Toxicol Sci. 2014 Jan;137(1):1-2
pubmed: 24213143
Nat Commun. 2019 Sep 17;10(1):4222
pubmed: 31530810
Int J Tuberc Lung Dis. 2020 Jun 1;24(6):570-576
pubmed: 32552993
Nat Genet. 2018 Jan;50(1):6-11
pubmed: 29255261
Brief Funct Genomics. 2015 Sep;14(5):369-79
pubmed: 25998059
Int J Epidemiol. 2016 Apr;45(2):382-8
pubmed: 27063603
Genetics. 1936 Sep;21(5):554-604
pubmed: 17246812
Environ Int. 2019 Feb;123:189-200
pubmed: 30530161
Int J Environ Res Public Health. 2017 Jul 12;14(7):
pubmed: 28704939
Genome Res. 2020 Dec;30(12):1802-1814
pubmed: 33203765
Int J Epidemiol. 2017 Oct 1;46(5):1392-1393k
pubmed: 29040580
Bioinformatics. 2011 Jun 1;27(11):1496-505
pubmed: 21471010
Nat Genet. 2005 Feb;37(2):129-37
pubmed: 15654335
F1000Res. 2014 Jul 30;3:175
pubmed: 25285208
Genome Res. 2012 Jun;22(6):1144-53
pubmed: 22399572
Genes (Basel). 2017 May 23;8(6):
pubmed: 28545252
Bioinformatics. 2014 Dec 1;30(23):3435-7
pubmed: 25147358
G3 (Bethesda). 2020 Feb 6;10(2):645-664
pubmed: 31888951
Int J Epidemiol. 2013 Aug;42(4):978-91
pubmed: 23064411
Essays Biochem. 2019 Dec 20;63(6):717-726
pubmed: 31782496
Genomics. 2012 Jan;99(1):25-35
pubmed: 22079941
Nat Rev Genet. 2008 Jun;9(6):465-76
pubmed: 18463664
PLoS One. 2015 Jun 24;10(6):e0100476
pubmed: 26107953
Int J Epidemiol. 2012 Aug;41(4):930-40
pubmed: 21471022
Epigenomics. 2013 Apr;5(2):177-94
pubmed: 23566095
J Am Board Fam Med. 2011 May-Jun;24(3):313-22
pubmed: 21551404
Biometrics. 2020 Mar;76(1):23-35
pubmed: 31424088
Int J Epidemiol. 2012 Feb;41(1):200-9
pubmed: 22422453
Genetics. 2006 May;173(1):419-34
pubmed: 16204214
Int J Epidemiol. 2016 Apr;45(2):353-63
pubmed: 26283636