Nitric oxide contributes to liver inflammation and parasitic burden control in Ascaris suum infection.
Ascariasis
Ascaris suum
Inflammatory molecule
Nitric oxide
Journal
Experimental parasitology
ISSN: 1090-2449
Titre abrégé: Exp Parasitol
Pays: United States
ID NLM: 0370713
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
29
11
2021
revised:
25
04
2022
accepted:
26
04
2022
pubmed:
14
5
2022
medline:
22
6
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Human ascariasis is one of the most prevalent neglected tropical diseases worldwide. The immune response during human ascariasis is characterized by Th2 polarization and a mixed Th2/Th17 response during the pathogenesis of experimental larval ascariasis. Cytokines and other pro-inflammatory mediators, such as nitric oxide (NO), are involved in helminthic infections. However, the role of NO in ascariasis remains unclear. Given the importance of NO in inflammation, we aimed to determine the immunological and histopathological alterations in the livers of C57BL/6 iNOS In this study, parasitic load was evaluated in the livers of wild type C57BL/6 and C57BL/6 iNOS The results showed that NO is important for controlling parasitic load during infection by A. suum. C57BL/6iNOS We demonstrated that NO is a crucial inflammatory molecule during Ascaris sp. infection and controls the establishment of the parasite and the development of the host immune response in the liver.
Sections du résumé
BACKGROUND
BACKGROUND
Human ascariasis is one of the most prevalent neglected tropical diseases worldwide. The immune response during human ascariasis is characterized by Th2 polarization and a mixed Th2/Th17 response during the pathogenesis of experimental larval ascariasis. Cytokines and other pro-inflammatory mediators, such as nitric oxide (NO), are involved in helminthic infections. However, the role of NO in ascariasis remains unclear.
OBJECTIVES
OBJECTIVE
Given the importance of NO in inflammation, we aimed to determine the immunological and histopathological alterations in the livers of C57BL/6 iNOS
METHODS
METHODS
In this study, parasitic load was evaluated in the livers of wild type C57BL/6 and C57BL/6 iNOS
RESULTS
RESULTS
The results showed that NO is important for controlling parasitic load during infection by A. suum. C57BL/6iNOS
CONCLUSIONS
CONCLUSIONS
We demonstrated that NO is a crucial inflammatory molecule during Ascaris sp. infection and controls the establishment of the parasite and the development of the host immune response in the liver.
Identifiants
pubmed: 35550886
pii: S0014-4894(22)00061-3
doi: 10.1016/j.exppara.2022.108267
pii:
doi:
Substances chimiques
Cytokines
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108267Informations de copyright
Copyright © 2022. Published by Elsevier Inc.