Impact of donor-to-recipient weight ratio on the hospital outcomes of pediatric heart transplantation.
Cardiac transplantation
Donor selection
Transplant recipient
Journal
The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology
ISSN: 2090-911X
Titre abrégé: Egypt Heart J
Pays: Germany
ID NLM: 9106952
Informations de publication
Date de publication:
13 May 2022
13 May 2022
Historique:
received:
04
02
2022
accepted:
23
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
Identifying the factors that can influence the prognosis and final outcomes of pediatric heart transplantation is important and makes it possible to prevent complications and improve outcomes. Coordination of donor characteristics with the recipient in terms of sex, weight, body mass index (BMI), and body surface area (BSA) is an important factor that can influence the outcome of the transplantation. There is still no consensus regarding the role of discrepancy in anthropometrics between donors and recipients. The aim of this study was to investigate the relationship between donor and recipient weight mismatch on the early outcomes of pediatric heart transplantation. In this historical cohort study, 80 children who had underwent heart transplantation for the first time between 2014 and 2019 in Shahid Rajaie Cardiovascular Medical and Research Center in Tehran, Iran, were enrolled and divided into three groups according to donor-to-recipient weight ratio (0.8 < D/RW ≤ 1.5, 1.5 < D/RW ≤ 2.5, and 2.5 < D/RW). The early outcomes of transplantation, during the first post-transplant month, including right heart failure, renal failure, graft rejection, inotrope dependency, duration of intubation, length of ICU stay, death and requiring extracorporeal membrane oxygenation, were recorded through reviewing patient records. Median donor-to-recipient BSA ratio was directly associated with higher vasoactive-inotropic score (P = 0.038), while no significant association was found between donor-to-recipient weight ratio and vasoactive-inotropic score (P = 0.07). No significant relationship was found between other outcomes and donor-to-recipient weight ratio or donor-to-recipient BSA ratio. Patients who require heart transplantation may also benefit from mismatch donors, especially in those with significant cardiomegaly.
Sections du résumé
BACKGROUND
BACKGROUND
Identifying the factors that can influence the prognosis and final outcomes of pediatric heart transplantation is important and makes it possible to prevent complications and improve outcomes. Coordination of donor characteristics with the recipient in terms of sex, weight, body mass index (BMI), and body surface area (BSA) is an important factor that can influence the outcome of the transplantation. There is still no consensus regarding the role of discrepancy in anthropometrics between donors and recipients. The aim of this study was to investigate the relationship between donor and recipient weight mismatch on the early outcomes of pediatric heart transplantation. In this historical cohort study, 80 children who had underwent heart transplantation for the first time between 2014 and 2019 in Shahid Rajaie Cardiovascular Medical and Research Center in Tehran, Iran, were enrolled and divided into three groups according to donor-to-recipient weight ratio (0.8 < D/RW ≤ 1.5, 1.5 < D/RW ≤ 2.5, and 2.5 < D/RW). The early outcomes of transplantation, during the first post-transplant month, including right heart failure, renal failure, graft rejection, inotrope dependency, duration of intubation, length of ICU stay, death and requiring extracorporeal membrane oxygenation, were recorded through reviewing patient records.
RESULTS
RESULTS
Median donor-to-recipient BSA ratio was directly associated with higher vasoactive-inotropic score (P = 0.038), while no significant association was found between donor-to-recipient weight ratio and vasoactive-inotropic score (P = 0.07). No significant relationship was found between other outcomes and donor-to-recipient weight ratio or donor-to-recipient BSA ratio.
CONCLUSIONS
CONCLUSIONS
Patients who require heart transplantation may also benefit from mismatch donors, especially in those with significant cardiomegaly.
Identifiants
pubmed: 35551518
doi: 10.1186/s43044-022-00276-8
pii: 10.1186/s43044-022-00276-8
pmc: PMC9106769
doi:
Types de publication
Journal Article
Langues
eng
Pagination
38Informations de copyright
© 2022. The Author(s).
Références
J Korean Med Sci. 2011 May;26(5):593-8
pubmed: 21532847
Ann Thorac Surg. 2018 Apr;105(4):1223-1230
pubmed: 29258675
J Thorac Cardiovasc Surg. 2013 Dec;146(6):1538-43
pubmed: 23915920
J Heart Lung Transplant. 2012 Jun;31(6):571-8
pubmed: 22381209
J Thorac Cardiovasc Surg. 1993 Sep;106(3):444-8
pubmed: 8361185
Pediatr Transplant. 2010 Sep 1;14(6):741-5
pubmed: 20214744
J Heart Lung Transplant. 2005 Aug;24(8):945-55
pubmed: 16102427
Pediatr Transplant. 2013 Dec;17(8):774-81
pubmed: 24102961
JAMA. 1986 Apr 11;255(14):1892-8
pubmed: 3512878
J Heart Lung Transplant. 2012 Oct;31(10):1052-64
pubmed: 22975095
J Heart Lung Transplant. 2008 Apr;27(4):408-15
pubmed: 18374877
Pediatr Transplant. 2016 Aug;20(5):652-7
pubmed: 27313116
Circ J. 2013;77(5):1097-110
pubmed: 23614963
J Cardiovasc Nurs. 2007 May-Jun;22(3):218-53
pubmed: 17545824
Circulation. 2008 Sep 30;118(14 Suppl):S83-8
pubmed: 18824775
J Heart Lung Transplant. 1996 Feb;15(2):190-5
pubmed: 8672523