Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate.
Cadinane-type sesquiterpenoids
Lignans
Quantum chemical calculation
Schisandra bicolor var. tuberculate
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
13 May 2022
13 May 2022
Historique:
received:
18
03
2022
accepted:
04
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7-13) were isolated from the stems of Schisandra bicolor var. tuberculate. The structures of 1-4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities.
Identifiants
pubmed: 35552885
doi: 10.1007/s13659-022-00342-3
pii: 10.1007/s13659-022-00342-3
pmc: PMC9098724
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19Subventions
Organisme : National Natural Science Foundation of China
ID : 81903520
Informations de copyright
© 2022. The Author(s).
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